Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — SYK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Qin et al., Biochemistry 2003 : Under our conditions, hydrogen peroxide induced PI3K and Akt activation was independent of Lyn, Syk , Cbl, BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Peruzzi et al., J Immunol 2007 (Calcium Signaling) : Altogether, our findings support a new role for CIN85 in regulating Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Lau et al., J Immunol 2008 : We postulated that Syk regulates PI3K activation and HRV endocytosis in the airway epithelium ... HRV induced PI3K activation was dependent on Syk ; Syk knockdown by small interfering RNA significantly decreased phosphorylation of the PI3K substrate Akt
Chiou et al., Eur J Pharmacol 2011 : Psoralidin inhibits LPS induced iNOS expression via repressing Syk mediated activation of PI3K-IKK-I?B signaling pathways
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production
Hatton et al., Am J Transplant 2013 (Epstein-Barr Virus Infections...) : Taken together, our data indicate that Syk activates PI3K/Akt signaling which is required for survival of EBV+ B cell lymphomas
Zheng et al., Exp Cell Res 2013 : Our data indicate that TMP might repress iNOS expression, at least in part, through its inhibitory effect of Syk mediated PI3K phosphorylation in TNF-a stimulated HUVECs