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IRF6 — TBK1

Text-mined interactions from Literome

Solis et al., Eur J Immunol 2007 : In human macrophages and macrophage activated killer cells, we demonstrate that ( i ) the type I IFN response to lipopolysaccharide (LPS) is weak compared to the host response to virus infection ; ( ii ) there is a temporal difference in the induction of tank binding kinase-1 (TBK1) and IkappaB kinase (IKK) related kinase epsilon ( IKKepsilon ) kinase activities in response to LPS , with TBK1 activated early and IKKepsilon induced in the late phase of IFN induction ; and ( iii ) interferon regulatory factor (IRF)-7 is induced following LPS treatment, but there is no evidence that IRF-7 becomes activated by phosphorylation in vivo
Tamassia et al., J Immunol 2007 : Moreover, we show that the upstream TANK binding kinase-1 is not activated by LPS in neutrophils
Schröder et al., EMBO J 2008 : Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon mediated IRF activation ... Here, we describe a novel VACV protein, K7, which can inhibit PRR induced IFN-beta induction by preventing TBK1/IKKepsilon mediated IRF activation ... Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon mediated IRF activation and Ifnb promoter induction
Balkhi et al., Cell Signal 2010 (Inflammation) : In infected cells, IRF-3 and IRF-7 are activated by TBK-1 and IKK epsilon mediated phosphorylation, while the kinase, phosphorylating IRF-5 in the MyD88 signalling pathway has not yet been identified
Ogasawara et al., Journal of clinical biochemistry and nutrition 2011 : Rebamipide reduced the expression of TBK1 , IRF3 and IRF7 mRNA induced by LPS/dsRNA , but not of NF-?B mRNA in colonic epithelial cells
Gleason et al., J Biol Chem 2011 : In contrast, LPS stimulated phosphorylation of OPTN ( D477N ) was markedly reduced in BMDMs from OPTN ( D477N/D477N ) mice, and inhibition of the canonical IKKs alone prevented phosphorylation, providing further evidence that ubiquitin binding to OPTN contributes to LPS induced TBK1 activation
Figueroa et al., J Immunol 2012 : Cells transfected with D299G TLR4 exhibited impaired LPS induced phosphorylation of p38 and TANK binding kinase 1 , activation of NF-?B and IFN regulatory factor 3, and induction of IL-8 and IFN-ß mRNA, whereas T399I TLR4 did not cause statistically significant inhibition