Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — TLR2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Lasunskaia et al., J Leukoc Biol 2006 (Tuberculosis) : Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through TLR2 dependent PI3K signaling ... The obtained data demonstrate that the direct effect of mycobacteria on macrophage shape might be mediated through TLR2 dependent PI3K activation
Guiducci et al., J Exp Med 2008 : We show that PI3K is activated by TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Hodson et al., Adv Exp Med Biol 2009 : Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009 : In this study we assess the role of p110 delta PI3K in TLR4, TLR9 , or TLR4+TLR9 mediated B cell responses
Wenink et al., J Immunol 2009 : The inhibitory effect of TLR2 on the release of TNF-alpha but not of IL-12p70 was mediated by PI3K
Shen et al., Infect Immun 2010 (Listeriosis) : Moreover, functional activation of PI3K and Rac1 was impaired in TLR2 ( -/- ) and MyD88 ( -/- ) macrophages
Li et al., J Neuroimmunol 2011 (Chronic Disease...) : Furthermore, stimulation of TLR2 by PGN induces protection from stress induced reduction in the number of splenocytes through PI3K ... Collectively, our study thus demonstrates that stimulation of TLR2 mediated PI3K signaling attenuates splenocyte reduction induced by stress, and that ß-arrestin 2 modulates TLR2 mediated immune response following stress
Toubiana et al., J Biol Chem 2011 : We report here that IMPDHII plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity
Schmid et al., Cancer Cell 2011 (Disease Progression...) : Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k? , a single convergent point promoting tumor inflammation and progression
Lu et al., J Immunol 2011 (Infarction, Middle Cerebral Artery...) : More significantly, either TLR2 deficiency or PI3K inhibition with LY29004 abolished the protection by Pam3CSK4
Troutman et al., Cell cycle (Georgetown, Tex.) 2012 (Inflammation) : Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on TLR mediated activation of PI3K and its impact on regulating cellular processes