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PIK3R1 — TLR4
Text-mined interactions from Literome
Ha et al., Cardiovasc Res 2005
(Cardiomegaly...) :
Our results demonstrate that
TLR4 is a novel receptor contributing to the development of cardiac hypertrophy in vivo and that both the TLR4 mediated pathway and
PI3K/Akt/mTOR signaling are
involved in the development of cardiac hypertrophy in vivo
Pinheiro da Silva et al., Nat Med 2007
(Escherichia coli Infections...) :
Decreased
PI3K activity inhibits E. coli phagocytosis and
increases TNF-alpha production through
Toll-like receptor 4
Guiducci et al., J Exp Med 2008
:
We show that
PI3K is
activated by
TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Schabbauer et al., Mol Immunol 2008
(Rhabdoviridae Infections) :
TLR4/CD14 mediated
PI3K activation is an essential component of interferon dependent VSV resistance in macrophages
Zhang et al., J Neuroimmunol 2008
(Disease Models, Animal) :
Our data demonstrated that
TLR4 negatively
regulates PI3K activity in wild type mice, leading to the observed the stress induced immune response ... Therefore, stress modulates the immune system through
TLR4 mediated
PI3K/Akt signaling
Hodson et al., Adv Exp Med Biol 2009
:
Although CD40,
TLR and cytokines all
activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009
:
In this study we assess the
role of p110 delta
PI3K in TLR4,
TLR9 , or TLR4+TLR9 mediated B cell responses ... In this study we assess the
role of p110 delta
PI3K in
TLR4 , TLR9, or TLR4+TLR9 mediated B cell responses
Doan et al., Anticancer Res 2009
(Colorectal Neoplasms) :
Our results identify
TLR4 expression in human CRCs and
activation of
PI3K with LPS treatment
Hsu et al., Cancer Res 2011
(Colorectal Neoplasms...) :
Taken together, the results indicate that stimulation of the
TLR4/MD2 complex by LPS
activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Schmid et al., Cancer Cell 2011
(Disease Progression...) :
Receptor tyrosine kinases and
TLR/IL1Rs unexpectedly
activate myeloid cell
PI3k? , a single convergent point promoting tumor inflammation and progression
Yang et al., Mol Biol Rep 2012
(Coronary Restenosis...) :
High mobility group box-1 induces migration of vascular smooth muscle cells via
TLR4 dependent
PI3K/Akt pathway
activation
Kim et al., J Clin Immunol 2012
(Acute Lung Injury) :
Additionally, infiltration of dendritic cells (DCs) and expression of
toll-like receptor 4 (TLR4) were significantly increased in the lung of LPS treated mice, and inhibition of
PI3K-? reduced the infiltration of DCs and TLR4 expression in the lung
Troutman et al., Cell cycle (Georgetown, Tex.) 2012
(Inflammation) :
Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on
TLR mediated activation of
PI3K and its impact on regulating cellular processes