Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — TLR5

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2006 : We demonstrate that silencing TLR5 expression in nontransformed human colonic epithelial cells blocks flagellin induced PI3K activation, indicating specific activation of PI3K by flagellin/TLR5 engagement ... Indeed, we demonstrate that the adaptor molecule MyD88 associates with TLR5 and silencing MyD88 expression blocks PI3K activation by disrupting the association between TLR5 and p85
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation) : We conclude that whereas PI3K is downstream of MUC1 activation and negatively regulates TLR5 signaling, it is not responsible for MUC1 induced suppression of TLR5 signaling
Guiducci et al., J Exp Med 2008 : We show that PI3K is activated by TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Hodson et al., Adv Exp Med Biol 2009 : Although CD40, TLR and cytokines all activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009 : In this study we assess the role of p110 delta PI3K in TLR4, TLR9 , or TLR4+TLR9 mediated B cell responses
Schmid et al., Cancer Cell 2011 (Disease Progression...) : Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k? , a single convergent point promoting tumor inflammation and progression
Troutman et al., Cell cycle (Georgetown, Tex.) 2012 (Inflammation) : Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on TLR mediated activation of PI3K and its impact on regulating cellular processes