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PIK3R1 — TLR5
Text-mined interactions from Literome
Rhee et al., J Biol Chem 2006
:
We demonstrate that silencing TLR5 expression in nontransformed human colonic epithelial cells blocks flagellin induced PI3K activation, indicating specific
activation of
PI3K by
flagellin/TLR5 engagement ... Indeed, we demonstrate that the adaptor molecule MyD88 associates with
TLR5 and silencing MyD88 expression
blocks PI3K activation by disrupting the association between TLR5 and p85
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation) :
We conclude that whereas
PI3K is downstream of MUC1 activation and negatively
regulates TLR5 signaling, it is not responsible for MUC1 induced suppression of TLR5 signaling
Guiducci et al., J Exp Med 2008
:
We show that
PI3K is
activated by
TLR stimulation in primary human pDCs and demonstrate, using specific inhibitors, that PI3K is required for type I IFN production by pDCs, both at the transcriptional and protein levels
Hodson et al., Adv Exp Med Biol 2009
:
Although CD40,
TLR and cytokines all
activate PI3K the BCR seems especially dependent upon PI3K signalling
Dil et al., Mol Immunol 2009
:
In this study we assess the
role of p110 delta
PI3K in TLR4,
TLR9 , or TLR4+TLR9 mediated B cell responses
Schmid et al., Cancer Cell 2011
(Disease Progression...) :
Receptor tyrosine kinases and
TLR/IL1Rs unexpectedly
activate myeloid cell
PI3k? , a single convergent point promoting tumor inflammation and progression
Troutman et al., Cell cycle (Georgetown, Tex.) 2012
(Inflammation) :
Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on
TLR mediated activation of
PI3K and its impact on regulating cellular processes