Gene interactions and pathways from curated databases and text-mining

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IL18 — TLR9

Text-mined interactions from Literome

Wagner et al., Curr Opin Microbiol 2002 (Bacterial Infections) : Interactions between CpG-DNA and TLR9 rapidly activate antigen presenting dendritic cells through the ancient Toll/IL-1-receptor signaling pathway to upregulate co-stimulatory molecules and to produce Th1 polarizing cytokines, such as interleukin-12 and interleukin-18
Netea et al., J Immunol 2004 (Chlamydophila Infections) : Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88 dependent, TLR2- and TLR4 independent induction of IL-18 release
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Li et al., J Immunol 2007 : Alum induced IL-1beta and IL-18 production was not due to enhancement of TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Zhu et al., J Biol Chem 2009 : Although pro-inflammatory cytokine and Ig production induced by CpG require TLR9 expression, we also found that SR-B1 negatively regulates TLR9 dependent production of interleukin-6, interleukin-10 , and IgM
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome ... TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice ... Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice