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TMED7 — TSC2

Text-mined interactions from Literome

Mancini et al., J Cell Biochem 2010 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Moreover, RAD 001 induced inhibition of Akt causes the de-phosphorylation of tuberous sclerosis tumor suppressor protein TSC2 at 14-3-3 binding sites, TSC2 release from 14-3-3 sigma ( restoring its inhibitory function on mTORC1 ) and nuclear import ( promoting the nuclear translocation of cyclin dependent kinase [ CDK ] inhibitor p27 ( Kip1 ), the stabilization of p27 ( Kip1 ) ligand with CDK2, and the G ( 0 ) /G ( 1 ) arrest )
Bhatia et al., Cell cycle (Georgetown, Tex.) 2010 (Medulloblastoma) : These results provide insight into the molecular ` hardwiring ' of the mitogenic network downstream of Shh signaling and emphasize the separate yet synergistic effects regulated by the TSC complex in (1) fueling proliferation through mTOR activation/GSK-3alpha/beta inactivation and ( 2 ) compromising checkpoint mechanisms via TSC2 dependent p27 ( Kip1 ) nuclear exclusion