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JAK1 — TNF

Text-mined interactions from Literome

Riley et al., J Biol Chem 1999 (Inflammation) : Herein, we demonstrate that the ability of IL-10 to inhibit tumor necrosis factor alpha (TNFalpha) production in lipopolysaccharide stimulated macrophages requires the presence of Stat3, Jak1 , and two distinct regions of the IL-10 receptor intracellular domain
Miscia et al., Cell Growth Differ 2002 (Lymphoma, B-Cell) : Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells ... Here we present evidence that TNF-alpha induces the activation of the cytoplasmic Janus tyrosine kinases Jak1 and Tyk2 in both human healthy peripheral and lymphoma B cells
Ait-Ali et al., Mol Endocrinol 2004 : Stimulatory effects of TNF-alpha on neuropeptide gene expression and release appeared to be mediated through the type 2 TNF-alpha receptor, and required activation of ERK 1/2 and p38, but not Janus kinase , MAPKs
Spencer et al., J Virol 2007 (Cytomegalovirus Infections) : However, inhibition of JAK1 had little effect on cmvIL-10 mediated suppression of tumor necrosis factor alpha (TNF-alpha) production
Yarilina et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Our findings demonstrate that JAK inhibitors suppress macrophage activation and attenuate TNF responses and further suggest that suppression of cytokine/chemokine production and innate immunity contribute to the therapeutic efficacy of JAK inhibitors
Nam et al., J Pept Sci 2012 : Inhibition of JAK ( STAT1/STAT5 kinase ) with AG490 markedly reduced the production of IL-6 and TNF-a in macrophages
Guo et al., J Immunol 1998 : Induction of Jak/STAT signaling by activation of the type 1 TNF receptor ... In this study, we show that murine TNF induces the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1 , Jak2, and Tyk2 in murine 3T3-L1 adipocytes ... Phosphorylation of Jak proteins was also induced by human TNF , which selectively binds to TNFR1 on murine cells