Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — TNF

Text-mined interactions from Literome

Miura et al., Biochim Biophys Acta 1999 (Insulin Resistance) : We have examined the effect of TNF-alpha on insulin induced glucose uptake and activations of tyrosine kinase, IRS-1, PI3K and PKC in rat adipocytes
Martelli et al., J Bone Miner Res 2000 : In contrast, intranuclear translocation of PI 3-K did not occur in response to the proapoptotic cytokine tumor necrosis factor alpha (TNF-alpha)
Buxadé et al., Immunology 2001 : The increase in translation of TNF-alpha due to serum could be inhibited by the phosphatidylinositol (PI) 3-K inhibitors, wortmannin and LY294002, suggesting that PI 3-K is involved in the translational control of TNF-alpha by serum
Osawa et al., J Immunol 2001 : TNF-alpha induced activations of PI3K and Akt were inhibited by DMS
Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation
Goetze et al., Biochem Biophys Res Commun 2001 : TNFalpha had no effect on insulin induced tyrosine-phosphorylation of IR or IRS-1, but inhibited insulin stimulated IRS-1/PI3K-association by 84 %
Hatano et al., Am J Physiol Gastrointest Liver Physiol 2001 : The PI3K inhibitor LY-294002 blocks TNF-alpha- and Fas mediated Akt phosphorylation
Kim et al., J Biol Chem 2004 : Down-regulation of PTEN by NIK/NF-kappaB results in activation of the PI3K/Akt pathway and augmentation of TNF-alpha induced PI3K/Akt stimulation
Williams et al., J Immunol 2004 (Disease Susceptibility...) : Inhibition of PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6, IL-10, IL-12, and TNF-alpha in septic mice
Scholz et al., J Invest Surg 2004 : We further showed that CD29/TNF-alpha mediated effects involved PI3K and tyrosine kinase dependent signaling via MAPK but were independent of nuclear transcription factor (NF)-kappaB activity
Kokkinakis et al., Cancer Lett 2006 (Neoplasms) : The response of tumors to MET-stress depends on their mutational status, however, it always involves inhibition of CDK1 and in most cases the upregulation of p21, p27, GADDs and 14-3-3sigma in response to upregulation of TGF-beta, IRF-1, TNF-alpha , Rb and/or MDA-7 and the downregulation of PI3K , RAS and NF-kappaB
Demirjian et al., Biochim Biophys Acta 2006 (MAP Kinase Signaling System) : On the other hand, the PI3-K inhibitor, LY294002, and epidermal growth factor receptor (EGFR)-specific inhibitor, AG1478, did not suppress the release of TNF-alpha
Mukai et al., Am J Physiol Heart Circ Physiol 2007 : PI3K inhibitors augmented TNF-alpha- and insulin induced phosphorylation of these MAPKs
Smith et al., J Bone Joint Surg Am 2007 (Prosthesis Failure) : The PI3K inhibitor reduced TNF-alpha production by 70 % in response to titanium with adherent endotoxin without increasing cytotoxicity ... High concentrations of endotoxin-free titanium particles resulted in a small delayed increase in TNF-alpha production that was completely blocked by the PI3K inhibitor
Pinheiro da Silva et al., Nat Med 2007 (Escherichia coli Infections...) : Decreased PI3K activity inhibits E. coli phagocytosis and increases TNF-alpha production through Toll-like receptor 4
Pincheira et al., J Immunol 2008 : Stimulation with TNF induces a time dependent change in the level of Jak2, c-Src, and PI3K associated with TNFR1
Tachado et al., J Biol Chem 2008 (HIV Infections...) : Taken together, these data demonstrate increased constitutive activation of the PI3K signaling pathway in HIV+ macrophages and support the concept that PI3K activation ( by HIV proteins such as Nef ) may contribute to reduced TLR4 mediated TNF-alpha release in HIV+ human macrophages and impair host cell response to infectious challenge
Kramer et al., Eur J Immunol 2009 : The limiting effect of PI3K on TNF-alpha production from activated monocytes depended on the decrease of GSK-3beta activity, which significantly reduced the transactivation of NF-kappaB
Wenink et al., J Immunol 2009 : The inhibitory effect of TLR2 on the release of TNF-alpha but not of IL-12p70 was mediated by PI3K
Tseng et al., J Cell Physiol 2010 : TNF-alpha increased the FAK, PI3K , and Akt phosphorylation
Saito et al., American journal of physiology. Renal physiology 2010 : TNF-alpha caused activation of NF-kappaB, MAP kinases, and PI3K-Akt in podocytes, whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha
Zhang et al., J Cell Mol Med 2011 (Endotoxemia...) : We conclude that PI3K mediated Rac1 activation is required for induction of TNF-a expression in cardiomyocytes and cardiac dysfunction during endotoxemia
Medina et al., J Immunol 2010 (Inflammation...) : In this study, we demonstrate that the induction of TNF and IL-6 expression by LVS in mouse bone marrow derived macrophages was markedly enhanced when PI3K activity was inhibited by either of the well-known chemical inhibitors, wortmannin or LY294002
Kim et al., Immune network 2011 : Both TNF-a and IL-6 production by HBHA was regulated by the NF-?B, PI3-K , and MAPK pathways
Lu et al., J Clin Immunol 2013 (Arthritis, Rheumatoid...) : We found that MAPK and Akt inhibitors, but not PI3K inhibitor, remarkably suppressed ACPA mediated TNF-a production
Zheng et al., Exp Cell Res 2013 : TMP significantly inhibited TNF-a induced phosphorylation of Syk and PI3K