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IFNG — TNFSF13B
Text-mined interactions from Literome
Moore et al., Science 1999
:
BLyS expression on human monocytes could be
up-regulated by
interferon-gamma
Nardelli et al., Blood 2001
:
The expression of
BLyS on monocyte membranes was retained following differentiation into macrophages, but detection on the surface of monocyte derived dendritic cells
required stimulation with
IFN-gamma ... Both
IFN-gamma and IL-10
enhanced the release of soluble
BLyS that was active in B-cell proliferation assays
Alsaleh et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
Moreover, we found that
IFNgamma induced
BAFF synthesis is inhibited by simultaneous stimulation with either TLR ligands or TNFalpha ... In contrast, we demonstrated that stimulation of alpha5beta1 integrin can induce BAFF synthesis and release per se and that stimulation of this pathway has no inhibitory effect on
IFNgamma induced
BAFF synthesis
Reyes et al., Cytokine 2008
(Arthritis, Rheumatoid) :
Moreover, Dex suppressed both mRNA and protein BAFF expression induced by TNF-alpha but had no effect on
IFN-gamma induced
BAFF expression
Kim et al., J Leukoc Biol 2008
:
In the present study, we examined the pathways by which TGF-beta1 and
IFN-gamma induce
BAFF expression to see if TGF-beta1 and IFN-gamma regulate B cell differentiation via macrophages ...
IFN-gamma further
augmented TGF-beta1 induced
BAFF expression ...
IFN-gamma caused phosphorylation of CREB, and overexpression of CREB
increased IFN-gamma induced
BAFF promoter activity ... Neither Stat1alpha ( a well-known transducing molecule of IFN-gamma ) nor AG490 ( a JAK inhibitor ) affected
BAFF expression in
response to
IFN-gamma
Jiang et al., Eur J Haematol 2009
(Multiple Myeloma) :
We also found that
IFN-gamma and IL-6 can
induce BLyS expression on MM cells, while after the treatment of BAY11-7082, an IkB-alpha phosphorylation inhibitor, IFN-gamma induced up regulation of BLyS was completely inhibited, suggesting that nuclear factor kappaB (NF-kappaB) might be involved in the mechanism of the regulation of BLyS levels in response to cytokines
Parameswaran et al., Clin Immunol 2009
(Lupus Erythematosus, Systemic) :
In addition,
IFN-gamma and IL-10, which
induce BAFF secretion, were down-regulated in hCDR1 treated mice
Tarantino et al., J Viral Hepat 2009
(Hepatitis C...) :
BLyS/BAFF expression by macrophages is
stimulated by
interferon-gamma and interleukin-10, and its serum levels are increased in chronic hepatitis C ( CHC )
Zhu et al., Blood 2009
(Purpura, Thrombocytopenic, Idiopathic) :
The
effects of recombinant human
BAFF ( rhBAFF ) and BAFF-R-Fc fusion protein ( BR3-Fc ) on B cells, T cells, platelets, secretion of
interferon gamma (IFNgamma) , and interleukin-4 (IL-4) were measured by flow cytometry and ELISA