Gene interactions and pathways from curated databases and text-mining

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CAPN11 — TP53

Text-mined interactions from Literome

Sedding et al., FASEB J 2008 : Prevention of calpain activation by calpeptin or antisense oligonucleotides augmented strain induced p53 expression and transcriptional activity, resulting in a further increase of apoptotic rate
Hama et al., J Pharmacol Sci 2009 : Excitotoxicity associated p53 expression in adult rat retina is mediated by calpain activity but not by Cl- influx
Woo et al., J Biol Chem 2012 (Ovarian Neoplasms) : Here, we present evidence that CDDP promotes calpain mediated PARC down-regulation, mitochondrial and nuclear p53 accumulation, and apoptosis in chemosensitive but not resistant OVCA cells