Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — TP53

Text-mined interactions from Literome

Bar et al., Cell Death Differ 2005 : The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy induced apoptosis ... These findings invoke an unexpected positive role for PI3K in p53 activation by anticancer agents, and suggest that the efficacy of PI3K inhibitors in cancer therapy may be greatly affected by the tumor p53 status
Filiz et al., Int J Biochem Cell Biol 2008 : Furthermore, CQ inhibited H2O2 mediated up-regulation of p53 activity in the M17 cells and this was dependent on PI3K activation
Kok et al., Trends Biochem Sci 2009 (Neoplasms) : Recently identified mechanisms that control PI3K production include increased gene copy number in cancer, and transcriptional regulation of the p110alpha PI3K gene by FOXO3a, NF-kappaB and p53 , and of the PI3K regulatory subunits by STAT3, EBNA-2 and SREBP
Li et al., Cancer Lett 2009 (Adenocarcinoma...) : Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation
Zhou et al., Cell Mol Immunol 2009 : PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis
Zhang et al., Int J Radiat Oncol Biol Phys 2012 (Lung Injury...) : Apoptosis correlated with increased PTEN expression, inhibition of downstream PI3K/AKT signaling, and increased p53 and Bax protein levels
Habib et al., Genes & cancer 2011 : These novel data provide evidence that loss of TSC-2, PTEN, and p53 as well as activation of PI 3-K and mTOR is associated with kidney cancer in the Eker rat, while sustained expression of TSC-2, PTEN, and p53 may prevent progression of kidney cancer in TSC patients
Bhowmick et al., J Virol 2013 (Rotavirus Infections) : This function of NSP1 was independent of its interferon or phosphatidylinositol 3-kinase (PI3K)/AKT modulation activity since p53 degradation was observed in Vero cells as well as in the presence of PI3K inhibitor
Chou et al., Toxicol In Vitro 2013 : A specific PI3K inhibitor attenuated the UVB induced ERK1/2 and p53 phosphorylation