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TP53 — VDR

Pathways - manually collected, often from reviews:

• FastForward regulation: TP53 → VDR (transcriptional regulation, increase) Maruyama et al., Cancer Res 2006*
  Evidence: REG, PROMACTIVITY, DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VDR — TP53 (physical association, affinity chromatography technology) Stambolsky et al., Cancer Cell 2010*
• IRef Intact Interaction: VDR — TP53 (colocalization, fluorescence microscopy) Stambolsky et al., Cancer Cell 2010*
• IRef Intact Interaction: VDR — TP53 (physical association, anti bait coimmunoprecipitation) Stambolsky et al., Cancer Cell 2010*

Text-mined interactions from Literome

Maruyama et al., Cancer Res 2006 : VDR is induced by p53 as well as several other p53 family members, and analysis of chromatin immunoprecipitation showed that p53 protein binds to conserved intronic sequences of the VDR gene in vivo ... In addition, p53 induced VDR target genes in a vitamin D3-dependent manner
Kommagani et al., J Biol Chem 2007 : Differential regulation of vitamin D receptor (VDR) by the p53 Family : p73 dependent induction of VDR upon DNA damage ... In this report, we examined whether p53 affects p63 mediated induction of VDR and studied the effect of DNA damage on VDR induction in p53 null cell lines ... Our results demonstrate that p53 itself does not induce VDR expression, nor does it affect p63 mediated VDR induction in the cell lines tested in this study
Sequeira et al., Mol Endocrinol 2012 : This up-regulation of p53, however, was observed in all mutant fibroblasts, including those with no VDR, and with Ab099 ; therefore, VDR and ERp57 are not essential for p53 regulation