Gene interactions and pathways from curated databases and text-mining

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PDLIM7 — TRAF4

Text-mined interactions from Literome

Murray et al., Hum Pathol 2001 (Epstein-Barr Virus Infections...) : In vitro, TRAF1 is induced by LMP1 , and previous studies have suggested that expression of TRAF1 is higher in EBV associated tumors than in their EBV negative counterparts
Coffin et al., J Virol 2003 : Interestingly, LMP-1 's first two transmembrane domains are not sufficient for oligomerization or TRAF binding
Siegler et al., Mol Pathol 2003 (Epstein-Barr Virus Infections...) : These results suggest that in non-neoplastic lymphocytes, TRAF1 expression is dependent on the presence of LMP1 , and that in IM B cells in vivo, LMP1 associated signalling pathways are active
Ramalingam et al., Arch Pathol Lab Med 2003 (Lymphoproliferative Disorders) : Recently, it has been suggested that LMP-1 induced TRAF activation is important in the pathogenesis of PTLDs
Graham et al., J Immunol 2009 : LMP1 does n't induce TRAF degradation, and employs TRAF3 as a positive mediator of cell signaling, whereas CD40 signals are inhibited by TRAF3