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PDLIM7 — TRAF4
Text-mined interactions from Literome
Murray et al., Hum Pathol 2001
(Epstein-Barr Virus Infections...) :
In vitro,
TRAF1 is
induced by
LMP1 , and previous studies have suggested that expression of TRAF1 is higher in EBV associated tumors than in their EBV negative counterparts
Coffin et al., J Virol 2003
:
Interestingly,
LMP-1 's first two transmembrane domains are not
sufficient for oligomerization or
TRAF binding
Siegler et al., Mol Pathol 2003
(Epstein-Barr Virus Infections...) :
These results suggest that in non-neoplastic lymphocytes,
TRAF1 expression is
dependent on the presence of
LMP1 , and that in IM B cells in vivo, LMP1 associated signalling pathways are active
Ramalingam et al., Arch Pathol Lab Med 2003
(Lymphoproliferative Disorders) :
Recently, it has been suggested that
LMP-1 induced
TRAF activation is important in the pathogenesis of PTLDs
Graham et al., J Immunol 2009
:
LMP1 does n't
induce TRAF degradation, and employs TRAF3 as a positive mediator of cell signaling, whereas CD40 signals are inhibited by TRAF3