Takayanagi et al., Nature 2000
(Arthritis...) :
Furthermore, we provide evidence that the accelerated degradation of TRAF6 requires both its ubiquitination, which is initiated by RANKL, and IFN-gamma induced activation of the ubiquitin-proteasome system
Modarresi et al., Am J Pathol 2009
(Bone Demineralization, Pathologic...) :
In addition, the HIV PI ritonavir abrogated the interferon-gamma mediated degradation of the RANKL nuclear adapter protein TRAF6 , a physiological block to RANKL activity