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LEP — TRH

Text-mined interactions from Literome

Harris et al., J Clin Invest 2001 : Transcriptional regulation of the thyrotropin releasing hormone gene by leptin and melanocortin signaling ... The melanocortin system activates the TRH promoter through the phosphorylation and DNA binding of the cAMP response element binding protein ( CREB ), and leptin signaling directly regulates the TRH promoter through the phosphorylation of signal transducer and activator of transcription 3 ( Stat3 )
Mantzoros et al., J Clin Endocrinol Metab 2001 : Leptin stimulates biosynthesis of TRH in vitro and influences the activity of the hypothalamic-pituitary-thyroid axis in vivo in rodents
García et al., Hypertension 2002 : We propose that because leptin produces central TRH synthesis and release, obesity may induce hypertension through TRH system activation and that the TRH-leptin interaction may thus contribute to the strong association between hypertension and obesity
Bjørbaek et al., Recent Prog Horm Res 2004 : Regulation of the pro-opiomelanocortin (pomc) and the thyrotropin releasing hormone (trh) genes by leptin is particularly well understood
Guo et al., Endocrinology 2004 (Obesity) : The regulation of TRH gene expression in the paraventricular nucleus of the hypothalamus ( PVH ) by leptin is critical for normal function of the thyroid axis in rodents and humans
Sanchez et al., J Clin Invest 2004 : Combined, these findings suggest that leptin dependent stimulation of hypothalamic TRH expression involves both activation of trh transcription and stimulation of PC1 and PC2 expression, which lead to enhanced processing of proTRH into mature TRH
Fekete et al., Endocrinology 2006 : In addition, leptin prevented fasting induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels
Perello et al., Endocrinology 2006 : We previously have shown that leptin regulates proTRH in the paraventricular nucleus ( PVN ) of the hypothalamus through two pathways
Lechan et al., Prog Brain Res 2006 : Endotoxin administration, however, has the paradoxical effect of increasing circulating levels of leptin and melanocortin signaling and CART gene expression in arcuate nucleus neurons, but inhibiting TRH gene expression in hypophysiotropic neurons
Shibusawa et al., Cerebellum 2008 (Spinocerebellar Degenerations) : Recent investigations have revealed that TRH production is regulated directly at the transcriptional level by leptin , one of the adipocytokines that plays a critical role in feeding and energy expenditure
Perello et al., Am J Physiol Endocrinol Metab 2010 (Obesity) : The hypothalamic-pituitary-thyroid (HPT) axis is a major contributor in maintaining energy expenditure and body weight, and the adipocyte hormone leptin regulates this axis by increasing TRH levels in the fed state ... Leptin stimulates TRH directly in the hypothalamic paraventricular nucleus ( PVN ; direct pathway ) and indirectly by regulating proopiomelnocortin neurons in the hypothalamic arcuate nucleus ( ARC ; indirect pathway )
Ghamari-Langroudi et al., Mol Endocrinol 2010 : TRH gene expression is positively regulated by leptin
Carbone et al., Brain Res 2012 (Body Weight...) : Prepro-thyrotropin releasing hormone expressing neurons in the juxtaparaventricular region of the lateral hypothalamus are activated by leptin and altered by prenatal glucocorticoid exposure