Gene interactions and pathways from curated databases and text-mining

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AHSA1 — TXN

Text-mined interactions from Literome

Hashimoto et al., Biochem Biophys Res Commun 1999 : These results showed that overexpression of TRX negatively regulates p38 MAP kinase activation and p38 MAP kinase mediated IL-6 production by TNF-alpha stimulated cells, indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression
Yamawaki et al., J Clin Invest 2005 (Inflammation) : In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression
Limón-Pacheco et al., Free Radic Biol Med 2007 (MAP Kinase Signaling System) : A time related GSH depletion in the liver and kidney correlated with p38 ( MAPK ) phosphorylation and induction of thioredoxin 1 (Tx-1) transcription