Hashimoto et al., Biochem Biophys Res Commun 1999
:
These results showed that overexpression of TRX negatively regulates p38 MAP kinase activation and p38 MAP kinase mediated IL-6 production by TNF-alpha stimulated cells, indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression
Yamawaki et al., J Clin Invest 2005
(Inflammation) :
In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression
Limón-Pacheco et al., Free Radic Biol Med 2007
(MAP Kinase Signaling System) :
A time related GSH depletion in the liver and kidney correlated with p38 ( MAPK ) phosphorylation and induction of thioredoxin 1 (Tx-1) transcription