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IKBKB — UBE2N
Text-mined interactions from Literome
Habelhah et al., EMBO J 2004
:
Inhibition of
Ubc13 expression by RNAi
resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of
IKK or p38
Xu et al., Mol Cell 2009
:
We demonstrate that K63 of ubiquitin and the catalytic activity of
Ubc13 , an E2 that catalyzes K63 polyubiquitination, are
required for
IKK activation by IL-1beta, but surprisingly, not by TNFalpha
Culver et al., Mol Cell Biol 2010
:
IKK complex activation following hypoxia
requires Ubc13 but not the recently identified LUBAC ( linear ubiquitin chain assembly complex ) ubiquitin conjugation system
Melvin et al., Cell cycle (Georgetown, Tex.) 2011
:
TAK1 and
IKK activation is dependent upon the calcium calmodulin kinase, CaMK2 and
requires Ubc13 as the E2 ubiquitin conjugation enzyme