Gene interactions and pathways from curated databases and text-mining

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IKBKB — UBE2N

Text-mined interactions from Literome

Habelhah et al., EMBO J 2004 : Inhibition of Ubc13 expression by RNAi resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of IKK or p38
Xu et al., Mol Cell 2009 : We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination, are required for IKK activation by IL-1beta, but surprisingly, not by TNFalpha
Culver et al., Mol Cell Biol 2010 : IKK complex activation following hypoxia requires Ubc13 but not the recently identified LUBAC ( linear ubiquitin chain assembly complex ) ubiquitin conjugation system
Melvin et al., Cell cycle (Georgetown, Tex.) 2011 : TAK1 and IKK activation is dependent upon the calcium calmodulin kinase, CaMK2 and requires Ubc13 as the E2 ubiquitin conjugation enzyme