Gene interactions and pathways from curated databases and text-mining

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IRF6 — UCP2

Text-mined interactions from Literome

Kizaki et al., Proc Natl Acad Sci U S A 2002 : These findings suggest that the LPS stimulated signals suppress UCP2 expression by interrupting the function of intronic enhancer, leading to an up-regulation of intracellular reactive oxygen species, which activate the signal transduction cascade of NOS II expression, probably to ensure rapid and sufficient cellular responses to a microbial attack
Emre et al., Biochem J 2007 : Stimulation of murine bone marrow derived macrophages by LPS quickly down-regulated UCP2 through the JNK ( c-Jun N-terminal kinase ) and p38 pathways
Faggioni et al., Biochem Biophys Res Commun 1998 (Escherichia coli Infections) : Induction of UCP2 gene expression by LPS : a potential mechanism for increased thermogenesis during infection ... To identify potential mechanisms underlying the increased energy expenditure and heat production during infection, we investigated whether LPS and cytokines might increase UCP2 mRNA levels in mice
Cortez-Pinto et al., Biochem Biophys Res Commun 1998 : LPS induction of hepatocyte UCP-2 expression is virtually abolished by prior treatment of rats with neutralizing antibodies to tumor necrosis factor alpha (TNF)