Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Jung et al., Mol Biol Cell 2009 : ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery ... These findings demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling
Jung et al., Autophagy 2011 : In addition, ULK1 was found to bind raptor, induce its phosphorylation, and inhibit the kinase activity of mTORC1
Dunlop et al., Autophagy 2011 : Interestingly, ULK1 overexpression also increases phosphorylation of Raptor Ser863 and the mTOR autophosphorylation site, Ser2481 in a mTORC1 dependent manner