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EGFR — UTP18

Text-mined interactions from Literome

Ratchford et al., J Biol Chem 2010 : G protein coupled receptors have been shown to promote proteolytic release of EGFR ligands ; however, neutralizing antibodies to known ligands of the EGFR did not inhibit UTP induced EGFR phosphorylation ... Immunoprecipitation experiments indicated that UTP causes association of the EGFR with another member of the EGF receptor family, ErbB3 ... Furthermore, stimulation of HSG cells with UTP induced phosphorylation of ErbB3, and silencing of ErbB3 expression inhibited UTP induced phosphorylation of both ErbB3 and EGFR ... UTP induced phosphorylation of ErbB3 and EGFR was also inhibited by silencing the expression of the ErbB3 ligand neuregulin 1 (NRG1)
Boucher et al., Am J Pathol 2011 : Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair
van Baal et al., Int J Biochem Cell Biol 2012 : Stimulation of A431 cells with EGF, bradykinin or UTP increased EGFR phosphorylation at Thr654 in a PKC dependent manner
Soltoff et al., J Biol Chem 1998 : UTP , ionomycin, and phorbol ester ( phorbol 12-myristate 13-acetate ) increased MAP kinase activity and also promoted the tyrosine phosphorylation of RAFTK, the epidermal growth factor (EGF) receptor , SHC, and p120 ( cbl )