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APOB — VCAM1
Text-mined interactions from Literome
Cominacini et al., Cell adhesion and communication 1999
:
Oxidized
LDL not only
caused a dose dependent increase of ICAM-1,
VCAM-1 and E-selectin ( p < 0.001 ), but also synergically increased their TNF-alpha induced expression ( p < 0.001 )
Colomé et al., Atherosclerosis 2000
(Arteriosclerosis) :
LDL did not
induce the expression of the intercellular cell adhesion molecule-1 ( ICAM-1 ),
vascular cell adhesion molecule-1 ( VCAM-1 ) or E-selectin, but it produced a downregulation of endothelial nitric oxide synthase ( NOS III ) mRNA levels
Cominacini et al., Am J Hypertens 2002
:
Although zofenoprilat significantly and dose dependently reduced the expression of
vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular cell adhesion molecule-1 ( ICAM-1 ), and E-selectin
induced by
ox-LDL ( P < .01 ) and TNF-alpha ( P < .01 ) on HUVECs, enalaprilat did not
Rosenson et al., Clin Sci (Lond) 2004
(Hypercholesterolemia) :
In contrast with the known
effects of oxidized
LDL on gene activation of ICAM-1 and
VCAM-1 , lag times did not correlate with sICAM-1 and sVCAM-1
Cai et al., Circulation 2004
(Cardiovascular Diseases...) :
In contrast to Db-LAGE-LD and native LDL,
Db-HAGE-LDL induced significant soluble
vascular cell adhesion molecule-1 production ( 2.3-fold ), which was blocked by PD98059, NAC, and DPI
Chen et al., Hypertension 2005
:
Compared with untransfected cells,
ox-LDL treatment ( 50 microg/mL, 24 hours ) markedly
induced the expression of the leukocyte adhesion molecules intercellular adhesion molecule-1 ( ICAM-1 ), and vascular cell adhesion molecule-1
(VCAM)-1 as well as matrix metalloproteinase (MMP)-1 in cells transfected with CMV-LOX-1wt ( P < 0.05 ) but not in cells transfected with CMV-LOX-1 ( 1-261 )
Zhu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2005
:
On the contrary,
ox-LDL did not
affect the expression of
VCAM-1 by HUVECs
Miyoshi et al., Atherosclerosis 2006
(Atherosclerosis...) :
MM-LDL resulted in dramatic induction of MCP-1,
VCAM-1 , and HO-1 mRNAs in the cells from B6 mice but exerted little effect in cells from C3H mice ... B6 cells produced significantly more MCP-1 and
VCAM-1 proteins in
response to
MM-LDL than C3H cells
Verna et al., Arterioscler Thromb Vasc Biol 2006
:
Using tail vein injection of LDL into LDLR ( -/- ) mice, we were able to maintain atherogenic
LDL blood levels, which
induced ICAM-1 and
VCAM-1 expression in their aortic endothelial cells after 24 hours ... Elevated
LDL blood levels, maintained in vivo,
increased the expression of the adhesion molecules ICAM-1 and
VCAM-1 in aortic endothelial cells
Lei et al., J Nutr 2008
:
These results suggest that the suppression of
ox-LDL induced E-selectin and
VCAM-1 expression by DADS and DATS and, thus, monocyte adhesion to endothelial cells is likely dependent on the PI3K/PKB or PKA/CREB signaling pathway in an adhesion molecule-specific manner
Cheng et al., Acta Pharmacol Sin 2009
(Atherosclerosis) :
DHEA could also reduce
ox-LDL induced MCP-1 and
VCAM-1 expression in untransfected or transfected VSMCs
Zhang et al., Mediators Inflamm 2013
:
Expressions of ICAM-1, PECAM-1, and
VCAM-1 as well as the levels of intracellular Ca ( 2+ ) are also markedly
increased by
ox-LDL in a dose dependent manner
Thorne et al., Atherosclerosis 1996
(Coronary Artery Disease) :
Modified
LDL also induced a significant 3-fold increase in monocyte adhesion to SMCs, but did not
induce VCAM-1 or ICAM-1 expression, nor was this adhesion inhibited by neutralising antibodies to VCAM-1 or ICAM-1
Lin et al., Atherosclerosis 1996
(Arteriosclerosis) :
The findings presented here link an atheogenic lipoprotein, LDL, with the induction of an adhesion molecule important in atherogenesis Human
LDL induces the
vascular cell adhesion molecule-1 ( VCAM-1 ) transcriptionally with an increase in mRNA levels through activation of the VCAM promoter
Cominacini et al., J Hypertens 1997
:
The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1,
VCAM-1 and E-selectin
induced by TNF-alpha alone or with oxidized
LDL ( P < 0.001 )