Gene interactions and pathways from curated databases and text-mining

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PARP14 — VEGFA

Text-mined interactions from Literome

Obrosova et al., Int J Mol Med 2004 (Diabetes Mellitus, Experimental...) : In conclusion, PARP is involved in diabetes- and hypoxia induced VEGF production at post-transcriptional level, downstream from the sorbitol pathway activation and oxidative stress
Zheng et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : Simvastatin significantly upregulated PGC-1alpha ( P < 0.01 ), subsequently decreased Deltapsim ( P < 0.05 ) and ROS generation ( P < 0.01 ), inhibited PARP activation ( P < 0.01 ), and further reduced VEGF expression ( P < 0.01 ) and p38 MAPK activity ( P < 0.01 )
Sledge et al., Surg Oncol Clin N Am 2010 (Breast Neoplasms) : Novel targeted therapies under development, many currently being examined in the adjuvant setting, are also explored, including anti-vascular endothelial growth factor therapy, poly ( ADP ribose ) polymerase ( PARP ) inhibition for triple negative breast cancers, and agents targeting site-specific metastasis to the bone ( receptor activator of NF-kB [ RANK ] ligand inhibition )