Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — VEGFC

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Luangdilok et al., Eur J Cancer 2011 (Carcinoma, Squamous Cell...) : In both cell lines stimulated with endogenous or exogenous ligand, inhibition of MEK1/2 ( with U0126 or PD98059 ) or PI3K ( with PI-103 or LY294002 ) resulted in a marked reduction of EGFR induced VEGF-A expression, whereas exogenous EGF induced VEGF-C upregulation was blocked by inhibitors of MEK but not PI3K
Coso et al., PloS one 2012 : Furthermore, activation of PI3K/Akt by VEGF-C/VEGFR-3 resulted in phosphorylation of P70S6K, eNOS, PLC?1, and Erk1/2