◀ Back to PIK3R1
PIK3R1 — VEGFC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Luangdilok et al., Eur J Cancer 2011
(Carcinoma, Squamous Cell...) :
In both cell lines stimulated with endogenous or exogenous ligand, inhibition of MEK1/2 ( with U0126 or PD98059 ) or PI3K ( with PI-103 or LY294002 ) resulted in a marked reduction of EGFR induced VEGF-A expression, whereas exogenous EGF induced
VEGF-C upregulation was
blocked by inhibitors of MEK but not
PI3K
Coso et al., PloS one 2012
:
Furthermore,
activation of
PI3K/Akt by
VEGF-C/VEGFR-3 resulted in phosphorylation of P70S6K, eNOS, PLC?1, and Erk1/2