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PIK3R1 — XIAP
Text-mined interactions from Literome
Carter et al., Leukemia 2003
(Blast Crisis...) :
Neither these nor Akt inhibitor treated OCI-AML3 cells showed changes in XIAP levels, suggesting that
XIAP expression is
regulated by
PI3K downstream effectors other than Akt
Paling et al., J Biol Chem 2004
:
Treatment with the reversible
PI3K inhibitor, LY294002, or more specific
inhibition of class I (
A ) PI3K via regulated expression of dominant negative Deltap85, led to a reduction in the ability of LIF to maintain self-renewal, with cells concomitantly adopting a differentiated morphology
Iwase et al., Int J Oncol 2007
(Carcinoma, Squamous Cell...) :
Expression of Bcl-2, cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and
X-linked IAP was down-regulated, and expression of Bax was
up-regulated by
PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Wang et al., Cancer Lett 2010
(Ovarian Neoplasms) :
Meanwhile, the further study demonstrates that the chemoresistance caused by IL-6 is associated with increased expression of both multidrug resistance related genes ( MDR1 and GSTpi ) and apoptosis inhibitory proteins ( Bcl-2, Bcl-xL and
XIAP ), as well as
activation of Ras/MEK/ERK and
PI3K/Akt signaling
Zhang et al., Front Biosci (Elite Ed) 2011
:
Taken together, the present study demonstrates that T3 potentiates the cell survival action of FSH through Src- and
PI3K mediated
Xiap up-regulation and decreased Fas and FasL expression
Veillette et al., Biol Reprod 2013
:
PI3-K inhibition in vivo blocked Akt phosphorylation, reduced Smad2 phosphorylation, and
reduced both TGF-beta2 and
XIAP expression