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PIK3R1 — ZGLP1
Text-mined interactions from Literome
Trümper et al., Ann N Y Acad Sci 2000
:
In contrast,
GLP-1 induced
PI 3-K activity mainly in Gab-1 and also in IRS-2 immunoprecipitates, although in an attenuated kinetic
Redondo et al., Mol Cell Endocrinol 2003
:
GLP-1 , like insulin,
activates PI3K/PKB , p70s6k, p44 and p42 MAP-kinase
Acitores et al., J Endocrinol 2004
:
We first explored the
effect of
GLP-1 , compared with that of insulin, on the activation of
PI3K , PKB, p70s6 kinase (p70s6k) and p44/42 mitogen activated protein kinases ( MAPKs ) and the action of specific inhibitors of these kinases on the insulin- and GLP-1 induced increment in glycogen synthase a activity ... The study showed that
GLP-1 , like insulin,
activated PI3K/PKB , p70s6k and p44/42
González et al., Regul Pept 2005
:
In conclusion,
GLP-1 , like insulin, stimulates glucose uptake, and this
involves activation of
PI3K/PKB , p44/42 MAPKs, partially p70s6k, and possibly PKC ; Ex-4 and Ex-9 both have GLP-1-like effect upon glucose transport, in which both share with GLP-1 an activation of PI3K/PKB -- partially in the case of Ex-4 -- and p44/42 MAPKs but not p70s6k
Sancho et al., Int J Mol Med 2007
(Obesity, Morbid) :
In addition,
GLP-1 and Ex-4
stimulated PI3K and MAPKs, similar to insulin, but not PKB