Gene interactions and pathways from curated databases and text-mining

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PIK3R1 — ZGLP1

Text-mined interactions from Literome

Trümper et al., Ann N Y Acad Sci 2000 : In contrast, GLP-1 induced PI 3-K activity mainly in Gab-1 and also in IRS-2 immunoprecipitates, although in an attenuated kinetic
Redondo et al., Mol Cell Endocrinol 2003 : GLP-1 , like insulin, activates PI3K/PKB , p70s6k, p44 and p42 MAP-kinase
Acitores et al., J Endocrinol 2004 : We first explored the effect of GLP-1 , compared with that of insulin, on the activation of PI3K , PKB, p70s6 kinase (p70s6k) and p44/42 mitogen activated protein kinases ( MAPKs ) and the action of specific inhibitors of these kinases on the insulin- and GLP-1 induced increment in glycogen synthase a activity ... The study showed that GLP-1 , like insulin, activated PI3K/PKB , p70s6k and p44/42
González et al., Regul Pept 2005 : In conclusion, GLP-1 , like insulin, stimulates glucose uptake, and this involves activation of PI3K/PKB , p44/42 MAPKs, partially p70s6k, and possibly PKC ; Ex-4 and Ex-9 both have GLP-1-like effect upon glucose transport, in which both share with GLP-1 an activation of PI3K/PKB -- partially in the case of Ex-4 -- and p44/42 MAPKs but not p70s6k
Sancho et al., Int J Mol Med 2007 (Obesity, Morbid) : In addition, GLP-1 and Ex-4 stimulated PI3K and MAPKs, similar to insulin, but not PKB