UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to TRAF6

TRAF6 — ZNF274

Pathways - manually collected, often from reviews:

KEGG Neurotrophin signaling pathway: TRAF6 → ZNF274 (protein-protein, ubiquination)
NCI Pathway Database p75(NTR)-mediated signaling: JNK family (MAPK8/MAPK9/MAPK10) → proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274) (modification, collaborate)
Khursigara et al., J Neurosci 2001, Gentry et al., J Biol Chem 2004, Yeiser et al., J Neurosci 2004, Linggi et al., J Biol Chem 2005, Casaccia-Bonnefil et al., Nature 1996
Evidence: mutant phenotype, assay, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) → NRIF (ZNF274) (modification, collaborate) Geetha et al., EMBO J 2005, Kenchappa et al., Neuron 2006
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) → Sortilin/TRAF6 complex (SORT1-TRAF6) (modification, collaborate)
Geetha et al., EMBO J 2005, Kenchappa et al., Neuron 2006
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: NRIF (ZNF274) → Sortilin/TRAF6 complex (SORT1-TRAF6) (modification, collaborate)
Geetha et al., EMBO J 2005, Kenchappa et al., Neuron 2006
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGFR-BDNF-SORT1-TRAF6) → NRIF (ZNF274) (modification, collaborate) Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling: proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGFR-BDNF-SORT1-TRAF6) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, collaborate)
Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling: NRIF (ZNF274) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, collaborate)
Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: mutant phenotype, assay, other species
NCI Pathway Database p75(NTR)-mediated signaling: Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) → p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) (modification, collaborate)
Kenchappa et al., Neuron 2006
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) → Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B) (modification, collaborate)
Kenchappa et al., Neuron 2006
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: JNK family (MAPK8/MAPK9/MAPK10) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, collaborate)
Khursigara et al., J Neurosci 2001, Yeiser et al., J Neurosci 2004, Linggi et al., J Biol Chem 2005
Evidence: mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: NRIF (ZNF274) → proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274) (modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
NCI Pathway Database p75(NTR)-mediated signaling: NRIF (ZNF274) → proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGF-NGFR-SORT1-TRAF6) (modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
NCI Pathway Database p75(NTR)-mediated signaling: proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274) → proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGF-NGFR-SORT1-TRAF6) (modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
NCI Pathway Database p75(NTR)-mediated signaling: proBDNF (dimer)/p75 ECD complex (BDNF) → p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) (modification, collaborate)
Weskamp et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: proBDNF (dimer)/p75 ECD complex (BDNF) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, collaborate)
Weskamp et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: p75 CTF/Sortilin/TRAF6/NRIF complex (SORT1-TRAF6-ZNF274) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, collaborate)
Weskamp et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database p75(NTR)-mediated signaling: TACE (ADAM17) → proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGFR-BDNF-SORT1-TRAF6-ZNF274) (modification, activates)
Weskamp et al., J Biol Chem 2004
Evidence: mutant phenotype, other species