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HMGB1 — IRF6
Pathways - manually collected, often from reviews:
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
ATF-2 (ATF2)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
HMG1 (HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
HMG1 (HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50 complex (RELA)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
IRF (IRF5/IRF1/IRF3/IRF6/IRF7/IRF4/IRF2)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
PCAF
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
PCAF
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1 complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
histone transacetylase (CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
histone transacetylase (CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
-
BioCarta the information processing pathway at the ifn beta enhancer:
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP)
→
RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB)
(modification, collaborate)
Text-mined interactions from Literome
Hasunuma et al., J Endotoxin Res 2002
(Shock, Septic) :
The
role of
high mobility group-1 protein (HMG-1) in
LPS- and TNF-alpha induced lethal shock in galactosamine (GalN) sensitized mice was investigated
Chen et al., J Leukoc Biol 2004
(Endotoxemia) :
Here, we demonstrated that genetic disruption of CD14 expression abrogated LPS induced TNF production but only partially attenuated
LPS induced
HMGB1 release in cultures of primary murine peritoneal macrophages ... Pharmacological suppression of p38 or ERK1/2 MAPK with specific inhibitors ( SB203580, SB202190, U0126, or PD98059 ) significantly attenuated LPS induced TNF production but failed to inhibit
LPS induced
HMGB1 release ... Consistently, an endogenous, immunosuppressive molecule, spermine, failed to inhibit LPS induced activation of p38 MAPK and yet, still significantly attenuated
LPS mediated
HMGB1 release
Mullins et al., Scand J Immunol 2004
:
Here, we report that
HMGB1 is released from human umbilical vein endothelial cells ( HUVEC ) in
response to
lipopolysaccharide (LPS) and tumour necrosis factor (TNF)-alpha
Tang et al., Shock 2005
(Endotoxemia) :
Heat shock pretreatment significantly inhibited
LPS induced release of
HMGB1 and the translocation of HMGB1 from the nucleus to the cytoplasm in RAW 264.7 cells ... These findings suggest that the release of HMGB1 by LPS activated macrophages is a late event in the pathogenesis of sepsis and that HSR could inhibit the release and translocation of
HMGB1 induced by
LPS
Killeen et al., J Pharmacol Exp Ther 2006
:
Treating these cells with pyrrolidine dithiocarbamate, SN50 ( amino acid sequence AAVALLPAVLLALLAPVQRKRQKLMP ) or 5- ( thien-3-yl ) -3-aminothiophene-2-carboxamide ( SC-514 ) also inhibited LPS induced NF-kappaB DNA binding, but these compounds failed to inhibit
LPS induced
HMGB1 secretion ... Incubating RAW 264.7 cells with either oltipraz or DL-sulforaphane inhibited
LPS induced
HMGB1 secretion
Jiang et al., J Immunol 2006
:
In these experiments, 1400W, an inhibitor of NO production by the inducible NO synthase, reduced HMGB1 release stimulated by LPS, but not poly ( I:C ), whereas neutralizing IFN-alpha prevented
HMGB1 release
induced by poly ( I:C ), but not
LPS ... Furthermore, inhibition of JNK activation attenuated
HMGB1 release
induced by either
LPS or poly ( I:C ) ... Together, these experiments indicate that, although both
LPS and poly ( I:C )
induce HMGB1 release from RAW 264.7 cells and murine macrophages, the response is differentially dependent on NO and IFN-alpha
Jiang et al., J Immunol 2007
:
In these experiments, using RAW 264.7 cells as a model,
LPS and poly ( I:C )
caused HMGB1 release into the medium whereas CpG ODN failed to induce this response
El Gazzar et al., Inflamm Res 2007
(Inflammation) :
LPS induced
HMGB1 release at 8 h and reached a peak at 48 h. Significant ( p < 0.05 ) production of TNFalpha, IL-1beta, IL-10, and TGF-beta1 was seen after 8 h
Zhao et al., Zhonghua Gan Zang Bing Za Zhi 2007
:
LPS could
increase HMGB1 expression of HC and KC and HMGB1 release from KC, but not from HC
Liu et al., Zhonghua Nei Ke Za Zhi 2007
:
Blocking of Rip2 could attenuate
LPS induced TNFalpha and
HMGB1 production
Jiang et al., Mol Immunol 2008
:
As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and
LPS , TLR3 and TLR4 ligands, respectively, can
induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Liu et al., Shock 2008
(Inflammation) :
These results indicate that KLF4 plays an important role in regulating the expression of HMGB1 in normal condition, as well as the translocation and release of
HMGB1 in
response to
LPS
Zhang et al., J Immunol 2008
:
Additionally,
LPS induced serine phosphorylation of
HMGB1 , which correlated with an interaction between CaMKIV and HMGB1 and with CaMKIV phosphorylation of HMGB1 in vitro ... Similarly, whereas CaMKIV ( +/+ ) Mphi showed serine phosphorylation of
HMGB1 in
response to
LPS , this phosphorylation was attenuated in CaMKIV ( -/- ) Mphi
Hagiwara et al., Crit Care Med 2009
(Acute Lung Injury...) :
Likewise,
LPS induced secretion of proinflammatory cytokines and
HMGB1 protein was inhibited by enalapril
Tang et al., Am J Respir Cell Mol Biol 2009
(MAP Kinase Signaling System...) :
Quercetin prevents
LPS induced
high-mobility group box 1 release and proinflammatory function ... Quercetin and autophagic inhibitor, wortmannin, inhibited
LPS induced type-II microtubule associated protein 1A/1B-light chain 3 production and aggregation, as well as
HMGB1 translocation and release, suggesting a potential association between autophagy and HMGB1 release
Nagato et al., Crit Care Med 2009
(Disease Models, Animal...) :
The increased levels of inflammatory cytokines and plasma
HMGB1 induced by
LPS in this rat model were improved by the administration of ART-123 ; additionally, reduced liver dysfunction and increased survival rate were observed
Hagiwara et al., Shock 2010
(Acute Lung Injury...) :
LPS induced secretion of proinflammatory cytokines and
HMGB1 protein was inhibited by treatment with rTM
Murakami et al., Int Immunol 2009
(Shock, Septic) :
LPS stimulation
induced the production of inflammatory cytokines and anandamide and release of
HMGB1 from RAW264.7 cells
Feghali et al., Oral Microbiol Immunol 2009
:
LPS from A. actinomycetemcomitans, P. gingivalis, and E. coli significantly
induced the production of
HMGB1 in a time dependent manner
Liu et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009
(Sepsis) :
Two kinds of cytokines, IL-6 and IL-8 could be up-regulated by
LPS and low concentration of HMGB1, and
HMGB1 acted as an inhibitor of LPS to down-regulate the expression and release of IL-6 and IL-8 from HepG2 cells
Qin et al., J Immunol 2009
(Arthritis, Experimental) :
These results demonstrate that
HMGB1 enhances the proinflammatory activity of
LPS by promoting the phosphorylation of MAPK p38 and by the activation of NF-kappaB through RAGE
Nabeyama et al., Proc Natl Acad Sci U S A 2010
(Cell Transformation, Neoplastic...) :
Macrophages from xCT ( mu/mu ) mice showed cell death in association with the excessive release of
high mobility group box chromosomal protein 1 upon
stimulation with
LPS , suggesting that xCT deficiency causes unremitting inflammation because of the impaired survival of activated macrophages at the inflammatory site
Hagiwara et al., Shock 2011
(Inflammation) :
Clopidogrel sulfate pretreatment also reduced
LPS induced
HMGB1 expression in lung and liver tissues
Li et al., PloS one 2011
(Disease Susceptibility...) :
The protection was associated with a significant reduction in systemic HMGB1 accumulation in vivo, and parallel inhibition of IFN-?- or
LPS induced
HMGB1 release in vitro
Li et al., Biochem Pharmacol 2011
:
Furthermore, EGCG stimulated LC3-II production and autophagosome formation, and inhibited
LPS induced
HMGB1 up-regulation and extracellular release
Wu et al., J Surg Res 2012
:
LPS induces
HMGB1 relocation and release by activating the NF-?B-CBP signal transduction pathway in the murine macrophage-like cell line RAW264.7
Zeng et al., Surgery 2012
(Genetic Predisposition to Disease...) :
The rs2249825 SNP and the haplotype TCG were significantly associated with
LPS induced
HMGB1 production by peripheral blood leukocytes
Jang et al., Antioxid Redox Signal 2012
(Sepsis) :
EP significantly inhibited the
lipopolysaccharide (LPS) stimulated inducible nitric oxide synthase (iNOS) expression and
high-mobility group box 1 (HMGB1) release in RAW 264.7 cells ... The inhibitory effect of EP on
LPS stimulated iNOS expression and
HMGB1 release was reversed by transfection with siHO-1RNA in RAW 264.7 cells, but EP failed to reduce them in HO-1 ( -/- ) peritoneal macrophages treated with LPS
Yang et al., Food Chem Toxicol 2012
:
In this study, we investigated this question by monitoring the effect of OA on
lipopolysaccharide (LPS) mediated release of
HMGB1 and the HMGB1 mediated modulation of inflammatory responses in human umbilical vein endothelial cells ( HUVECs )
Yin et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012
:
LPS can
induce HMGB1 translocation from nucleus to cytoplasm and across cellular membrane to the outside of CFs at a time dependent manner
Tseng et al., PloS one 2012
(Acute Lung Injury) :
This post-treatment also significantly attenuated
LPS induced activation of nuclear factor-?B ( NF-?B ) and the release of
high mobility group box 1 (HMGB1) in lung tissues
Zhu et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
We found that MBC extract dose-dependently attenuated
LPS induced release of
HMGB1 and several chemokines in macrophage cultures
Hwang et al., Mediators Inflamm 2012
:
Among the ligands of PPAR, the effect of rosiglitazone, a specific ligand for PPAR?, was superior in the inhibition of
HMGB1 release
induced by
LPS
Lee et al., Biochem Biophys Res Commun 2013
(Inflammation) :
Berberine significantly inhibited the
LPS stimulated NO production and
HMGB1 release in macrophages ... The inhibitory effect of berberine on
LPS stimulated NO and
HMGB1 release was reversed by siRNA-Nrf2, SB203580 ( p38 MAPK inhibitor ) and zinc protoporphyrin ( ZnPP ; HO-1 inhibitor ) within macrophages
Cao et al., PloS one 2013
(Peritonitis) :
In cultured HMrSV5 cells,
LPS actively
induced HMGB1 nuclear-cytoplasmic translocation and release in a time and dose dependent fashion
Pan et al., Chin Med J (Engl) 2013
:
Using cultures of peritoneal macrophages or RAW264.7 cells, in vitro
LPS stimulation
induced the release of
HMGB1 in an IRF-1 dependent manner ... And the janus associated kinase ( JAK ) -IRF-1 signal pathway appeared to participate in the signaling mechanisms of
LPS induced
HMGB1 release by mediating acetylation of HMGB1 ... IRF-1 plays a role in
LPS induced release of
HMGB1 and therefore may serve as a novel target in sepsis
Kawasaki et al., J Trauma Acute Care Surg 2013
:
In this study, we investigated the effects of DEX on
lipopolysaccharide (LPS) induced production of tumor necrosis factor a, interleukin 6 (IL-6), IL-8, and
high-mobility group box 1 protein in human whole blood
Hutchison et al., Glia 2013
:
Knockdown of miR-181 enhanced
LPS induced production of pro-inflammatory cytokines ( TNF-a, IL-6, IL-1ß, IL-8 ) and
HMGB1 , while overexpression of miR-181 resulted in a significant increase in the expression of the anti-inflammatory cytokine IL-10
Huang et al., Mol Med Report 2013
:
LPS induced secretion of the late pro-inflammatory cytokine
HMGB1 by liver cells is characterized by a late phase of release and smaller quantity, and the process of HMGB1 secretion appears to be associated with HMGB1 translocation
Li et al., Mol Med 2013
:
It was previously unknown whether panx-1 channel blockers can abrogate
lipopolysaccharide (LPS) induced PKR activation and
HMGB1 release in innate immune cells ... Here we demonstrated that a major gancao ( licorice ) component ( glycyrrhizin, or glycyrrhizic acid ) derivative, carbenoxolone ( CBX ), dose dependently abrogated
LPS induced
HMGB1 release in macrophage cultures with an estimated IC50 ˜ 5 µmol/L ... Collectively, these results suggested that CBX blocks
LPS induced
HMGB1 release possibly through impairing PKR activation, supporting the involvement of PKR in the regulation of HMGB1 release