Description: Homo sapiens ADAM metallopeptidase domain 19 (ADAM19), mRNA. RefSeq Summary (NM_033274): This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr5:156,904,312-157,002,831 Size: 98,520 Total Exon Count: 23 Strand: - Coding Region Position: hg19 chr5:156,907,957-157,002,704 Size: 94,748 Coding Exon Count: 23
Mental Disorders Ke-Sheng Wang et al. Schizophrenia research 2010, A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder., Schizophrenia research.
[PubMed 20889312]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00200 - Disintegrin PF01421 - Reprolysin (M12B) family zinc metalloprotease PF01562 - Reprolysin family propeptide PF08516 - ADAM cysteine-rich PF13574 - Metallo-peptidase family M12B Reprolysin-like PF13582 - Metallo-peptidase family M12B Reprolysin-like PF13583 - Metallo-peptidase family M12B Reprolysin-like PF13688 - Metallo-peptidase family M12
ModBase Predicted Comparative 3D Structure on Q9H013-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
