Description: Homo sapiens annexin A5 (ANXA5), mRNA. RefSeq Summary (NM_001154): The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]. Transcript (Including UTRs) Position: hg19 chr4:122,589,152-122,618,147 Size: 28,996 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chr4:122,589,623-122,617,744 Size: 28,122 Coding Exon Count: 12
ID:ANXA5_HUMAN DESCRIPTION: RecName: Full=Annexin A5; AltName: Full=Anchorin CII; AltName: Full=Annexin V; AltName: Full=Annexin-5; AltName: Full=Calphobindin I; Short=CBP-I; AltName: Full=Endonexin II; AltName: Full=Lipocortin V; AltName: Full=Placental anticoagulant protein 4; Short=PP4; AltName: Full=Placental anticoagulant protein I; Short=PAP-I; AltName: Full=Thromboplastin inhibitor; AltName: Full=Vascular anticoagulant-alpha; Short=VAC-alpha; FUNCTION: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. SUBUNIT: Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV). DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. DISEASE: Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:614391]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats. WEB RESOURCE: Name=R&D Systems' cytokine source book: Annexin V; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1063";
Diabetes Mellitus, Type 2 Paul R Burton et al. Nature 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls., Nature.
[PubMed 17554300]
pregnancy loss, recurrent Bogdanova, N. et al. 2007, A Common Haplotype of the Annexin A5 (ANXA5) Gene Promoter Is Associated with Recurrent Pregnancy Loss, Hum Mol Genet 2007.
[PubMed 17339269]
Pulmonary Disease, Chronic Obstructive Mateusz Siedlinski et al. Thorax 2011, Genome-wide association study of smoking behaviours in patients with COPD., Thorax.
[PubMed 21685187]
The authors identified two candidate regions associated with age at smoking initiation in patients with COPD.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08758
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
