Description: Homo sapiens Rho GTPase activating protein 29 (ARHGAP29), mRNA. RefSeq Summary (NM_004815): Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. [provided by RefSeq, Jun 2016]. Transcript (Including UTRs) Position: hg19 chr1:94,634,463-94,703,307 Size: 68,845 Total Exon Count: 23 Strand: - Coding Region Position: hg19 chr1:94,639,425-94,697,167 Size: 57,743 Coding Exon Count: 22
ID:RHG29_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 29; AltName: Full=PTPL1-associated RhoGAP protein 1; AltName: Full=Rho-type GTPase-activating protein 29; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. SUBUNIT: Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By similarity). TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. INDUCTION: Strongly down-regulated in mantle-cell lymphomas. Up- regulated in migrating glioma cells. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=AAH67839.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q52LW3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007266 Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
