Human Gene CDKN1A (uc021yzb.1)
  Description: Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2, mRNA.
RefSeq Summary (NM_078467): This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015].
Transcript (Including UTRs)
   Position: hg19 chr6:36,644,237-36,655,116 Size: 10,880 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr6:36,651,879-36,653,577 Size: 1,699 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:36,644,237-36,655,116)mRNA (may differ from genome)Protein (164 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDN1A_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase inhibitor 1; AltName: Full=CDK-interacting protein 1; AltName: Full=Melanoma differentiation-associated protein 6; Short=MDA-6; AltName: Full=p21;
FUNCTION: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
SUBUNIT: Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with PIM1.
INTERACTION: P78396:CCNA1; NbExp=2; IntAct=EBI-375077, EBI-375065; P20248:CCNA2; NbExp=2; IntAct=EBI-375077, EBI-457097; P24385:CCND1; NbExp=5; IntAct=EBI-375077, EBI-375001; P30281:CCND3; NbExp=3; IntAct=EBI-375077, EBI-375013; P24864:CCNE1; NbExp=7; IntAct=EBI-375077, EBI-519526; O96020:CCNE2; NbExp=2; IntAct=EBI-375077, EBI-375033; O94921:CDK14; NbExp=7; IntAct=EBI-375077, EBI-1043945; P24941:CDK2; NbExp=9; IntAct=EBI-375077, EBI-375096; P11802:CDK4; NbExp=4; IntAct=EBI-375077, EBI-295644; Q00535:CDK5; NbExp=2; IntAct=EBI-375077, EBI-1041567; Q9BQ15:NABP2; NbExp=7; IntAct=EBI-375077, EBI-2120336; P12004:PCNA; NbExp=4; IntAct=EBI-375077, EBI-358311; Q96FS4:SIPA1; NbExp=2; IntAct=EBI-375077, EBI-1054981;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
INDUCTION: Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.
DOMAIN: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
DOMAIN: The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex.
PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances CDKN1A stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability.
PTM: Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation.
PTM: Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).
SIMILARITY: Belongs to the CDI family.
SEQUENCE CAUTION: Sequence=AAB59559.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAB59560.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDKN1AID139.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdkn1a/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDKN1A
CDC HuGE Published Literature: CDKN1A
Positive Disease Associations: Basophils , bladder cancer , breast cancer , head and neck cancer , Lupus Erythematosus, Systemic|Lupus Nephritis , oral cancer , overall effect , Pancreatic Neoplasms , prostate cancer , stomach cancer
Related Studies:
  1. Basophils
    , , . [PubMed 0]
  2. bladder cancer
    Chen, W. C. et al. 2002, p21 gene codon 31 polymorphism is associated with bladder cancer., Urologic oncology. 2002 Mar-Apr;7(2):63-6. [PubMed 12474524]
    Although the mechanism is unclear, our results show p21 gene is associated with tumor grade.
  3. breast cancer
    Ma, H. et al. 2006, Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women, Int J Cancer 2006. [PubMed 16804901]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: CDKN1A
Diseases sorted by gene-association score: pancreatic cancer (14), gastrointestinal neuroendocrine tumor (12), cervical cancer, somatic (11), papilloma (11), tongue cancer (10), actinic cheilitis (10), invasive bladder transitional cell carcinoma (10), cervical adenocarcinoma (10), li-fraumeni syndrome (10), hepatocellular carcinoma (9), colorectal cancer (9), lung cancer (9), multiple endocrine neoplasia 1* (9), hypervitaminosis a (9), glioblastoma multiforme (8), atypical follicular adenoma (8), extramedullary plasmacytoma (8), bladder transitional cell papilloma (8), ataxia-telangiectasia (8), lip cancer (8), bladder cancer, somatic (7), retroperitoneal neuroblastoma (7), retinoblastoma (7), keratoacanthoma (7), urinary bladder cancer (7), retinal cancer (6), prostate cancer (6), sensory system cancer (6), breast cancer (6), breast adenocarcinoma (6), star syndrome (6), skin melanoma (6), adenocarcinoma in situ (6), nodular ganglioneuroblastoma (6), human t-cell leukemia virus type 1 (6), thyroid cancer (6), cheilitis (6), ogden syndrome (6), serous cystadenocarcinoma (5), endometrial cancer (5), osteochondroma (5), adenocarcinoma (5), melanoma (5), ocular cancer (5), chondromyxoid fibroma (5), skeletal muscle cancer (5), glioblastoma (4), testicular germ cell tumor (4), stomach cancer (4), nervous system cancer (4), nodular malignant melanoma (4), suppurative cholangitis (4), retinitis pigmentosa, y-linked (4), ovarian cancer, somatic (4), colon adenocarcinoma (3), malignant mesenchymoma (3), kidney cancer (2), oral squamous cell carcinoma (2), esophageal cancer (2), leukemia, acute promyelocytic, somatic (2), adamantinoma of long bones (1), gastrointestinal system cancer (1), reproductive organ cancer (1), gastric cancer, somatic (1), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 170.89 RPKM in Cells - Cultured fibroblasts
Total median expression: 2714.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.50102-0.319 Picture PostScript Text
3' UTR -581.491539-0.378 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003175 - CDI

Pfam Domains:
PF02234 - Cyclin-dependent kinase inhibitor

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1AXC - X-ray 2ZVV - X-ray 2ZVW - X-ray


ModBase Predicted Comparative 3D Structure on P38936
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019912 cyclin-dependent protein kinase activating kinase activity
GO:0030332 cyclin binding
GO:0031625 ubiquitin protein ligase binding
GO:0044877 macromolecular complex binding
GO:0046872 metal ion binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049 cell cycle
GO:0007050 cell cycle arrest
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0009411 response to UV
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010165 response to X-ray
GO:0010243 response to organonitrogen compound
GO:0010629 negative regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0019221 cytokine-mediated signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0031100 animal organ regeneration
GO:0031668 cellular response to extracellular stimulus
GO:0033158 regulation of protein import into nucleus, translocation
GO:0034198 cellular response to amino acid starvation
GO:0034605 cellular response to heat
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860 positive regulation of protein kinase activity
GO:0046685 response to arsenic-containing substance
GO:0048146 positive regulation of fibroblast proliferation
GO:0050821 protein stabilization
GO:0051384 response to glucocorticoid
GO:0051412 response to corticosterone
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060574 intestinal epithelial cell maturation
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0071493 cellular response to UV-B
GO:0071850 mitotic cell cycle arrest
GO:0072331 signal transduction by p53 class mediator
GO:0090398 cellular senescence
GO:0090399 replicative senescence
GO:0090400 stress-induced premature senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:1904030 negative regulation of cyclin-dependent protein kinase activity
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
GO:1904706 negative regulation of vascular smooth muscle cell proliferation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000278 regulation of DNA biosynthetic process
GO:2000379 positive regulation of reactive oxygen species metabolic process

Cellular Component:
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0032991 macromolecular complex
GO:0048471 perinuclear region of cytoplasm
GO:0070557 PCNA-p21 complex


-  Descriptions from all associated GenBank mRNAs
  AK298901 - Homo sapiens cDNA FLJ54803 complete cds, highly similar to Cyclin-dependent kinase inhibitor 1.
AK309512 - Homo sapiens cDNA, FLJ99553.
U09579 - Human melanoma differentiation associated (mda-6) mRNA, complete cds.
BC013967 - Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:8559 IMAGE:2822909), complete cds.
AB209881 - Homo sapiens mRNA for Cyclin-dependent kinase variant protein.
BC001935 - Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:4059 IMAGE:2823668), complete cds.
BC000312 - Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:8428 IMAGE:2821049), complete cds.
L25610 - Homo sapiens cyclin-dependent kinase inhibitor mRNA, complete cds.
L26165 - Human DNA synthesis inhibitor mRNA, complete cds.
U03106 - Human wild-type p53 activated fragment-1 (WAF1) mRNA, complete cds.
S67388 - p21=cyclin kinase inhibitor [human, lung, WI38, mRNA, 600 nt].
BC000275 - Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1), mRNA (cDNA clone MGC:3175 IMAGE:3355833), complete cds.
L47232 - Homo sapiens cyclin-dependent kinase (CIP1/WAF1) mRNA, with a mutation (Ser 31 to Arg) predisposing to cancer, 3' end.
L47233 - Homo sapiens cyclin-dependent kinase (CIP1/WAF1) mRNA, 3' end, with a cancer predisposing mutation in the 3' UTR.
AY008263 - Homo sapiens cyclin-dependent kinase inhibitor isoform mRNA, complete cds.
AB385124 - Synthetic construct DNA, clone: pF1KB5576, Homo sapiens CDKN1A gene for cyclin-dependent kinase inhibitor 1, complete cds, without stop codon, in Flexi system.
AM392711 - Synthetic construct Homo sapiens clone IMAGE:100002746 for hypothetical protein (CDKN1A gene).
AM392920 - Synthetic construct Homo sapiens clone IMAGE:100002996 for hypothetical protein (CDKN1A gene).
KJ905711 - Synthetic construct Homo sapiens clone ccsbBroadEn_15381 CDKN1A gene, encodes complete protein.
KJ890888 - Synthetic construct Homo sapiens clone ccsbBroadEn_00282 CDKN1A gene, encodes complete protein.
KR709732 - Synthetic construct Homo sapiens clone CCSBHm_00005563 CDKN1A (CDKN1A) mRNA, encodes complete protein.
KR709733 - Synthetic construct Homo sapiens clone CCSBHm_00005564 CDKN1A (CDKN1A) mRNA, encodes complete protein.
KR709734 - Synthetic construct Homo sapiens clone CCSBHm_00005565 CDKN1A (CDKN1A) mRNA, encodes complete protein.
KR709735 - Synthetic construct Homo sapiens clone CCSBHm_00005566 CDKN1A (CDKN1A) mRNA, encodes complete protein.
AB451422 - Homo sapiens CDKN1A mRNA for cyclin-dependent kinase inhibitor 1A, partial cds, clone: FLJ08131AAAF.
BT006719 - Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) mRNA, complete cds.
AB451290 - Homo sapiens CDKN1A mRNA for cyclin-dependent kinase inhibitor 1A, complete cds, clone: FLJ08131AAAN.
CR536533 - Homo sapiens full open reading frame cDNA clone RZPDo834A0522D for gene CDKN1A, cyclin-dependent kinase inhibitor 1A (p21, Cip1); complete cds, incl. stopcodon.
BC037414 - Homo sapiens cDNA clone IMAGE:4523867, **** WARNING: chimeric clone ****.
JD267732 - Sequence 248756 from Patent EP1572962.
JD510376 - Sequence 491400 from Patent EP1572962.
JD468828 - Sequence 449852 from Patent EP1572962.
JD191936 - Sequence 172960 from Patent EP1572962.
JD465077 - Sequence 446101 from Patent EP1572962.
JD417495 - Sequence 398519 from Patent EP1572962.
JD422960 - Sequence 403984 from Patent EP1572962.
JD303212 - Sequence 284236 from Patent EP1572962.
JD111546 - Sequence 92570 from Patent EP1572962.
JD206003 - Sequence 187027 from Patent EP1572962.
JD378049 - Sequence 359073 from Patent EP1572962.
JD269873 - Sequence 250897 from Patent EP1572962.
JD150362 - Sequence 131386 from Patent EP1572962.
JD039950 - Sequence 20974 from Patent EP1572962.
JD417429 - Sequence 398453 from Patent EP1572962.
JD317529 - Sequence 298553 from Patent EP1572962.
JD495061 - Sequence 476085 from Patent EP1572962.
JD540498 - Sequence 521522 from Patent EP1572962.
JD328981 - Sequence 310005 from Patent EP1572962.
JD399608 - Sequence 380632 from Patent EP1572962.
JD190730 - Sequence 171754 from Patent EP1572962.
JD218139 - Sequence 199163 from Patent EP1572962.
JD465409 - Sequence 446433 from Patent EP1572962.
JD390744 - Sequence 371768 from Patent EP1572962.
JD133128 - Sequence 114152 from Patent EP1572962.
JD133129 - Sequence 114153 from Patent EP1572962.
JD467074 - Sequence 448098 from Patent EP1572962.
JD467075 - Sequence 448099 from Patent EP1572962.
JD547265 - Sequence 528289 from Patent EP1572962.
JD226666 - Sequence 207690 from Patent EP1572962.
JD132466 - Sequence 113490 from Patent EP1572962.
JD544656 - Sequence 525680 from Patent EP1572962.
JD509892 - Sequence 490916 from Patent EP1572962.
JD288647 - Sequence 269671 from Patent EP1572962.
JD491405 - Sequence 472429 from Patent EP1572962.
JD040389 - Sequence 21413 from Patent EP1572962.
JD445656 - Sequence 426680 from Patent EP1572962.
JD114677 - Sequence 95701 from Patent EP1572962.
JD068823 - Sequence 49847 from Patent EP1572962.
MP067503 - Sequence 7 from Patent WO2018232288.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa05200 - Pathways in cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_g1Pathway - Cell Cycle: G1/S Check Point
h_p53Pathway - p53 Signaling Pathway
h_eponfkbPathway - Erythropoietin mediated neuroprotection through NF-kB
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_atmPathway - ATM Signaling Pathway
h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_cellcyclePathway - Cyclins and Cell Cycle Regulation

Reactome (by CSHL, EBI, and GO)

Protein P38936 (Reactome details) participates in the following event(s):

R-HSA-187828 Translocation of p21 to the nucleus
R-HSA-8852362 GTSE1 binds CDKN1A
R-HSA-198613 AKT phosphorylates p21Cip1 and p27Kip1
R-HSA-2399969 AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
R-HSA-8941915 Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21
R-HSA-187934 Inactivation of Cyclin A:Cdk2 complexes by p27/p21
R-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
R-HSA-187520 Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
R-HSA-187916 Cyclin A:Cdk2 mediated phosphorylation of p27/p21
R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
R-HSA-8942836 CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
R-HSA-187575 Ubiquitination of phospho-p27/p21
R-HSA-69227 Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
R-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
R-HSA-1226095 Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-8941855 RUNX3 regulates CDKN1A transcription
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69206 G1/S Transition
R-HSA-69242 S Phase
R-HSA-69275 G2/M Transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-2559583 Cellular Senescence
R-HSA-69560 Transcriptional activation of p53 responsive genes
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-212436 Generic Transcription Pathway
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-449147 Signaling by Interleukins
R-HSA-69236 G1 Phase
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
R-HSA-2262752 Cellular responses to stress
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5663202 Diseases of signal transduction
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1640170 Cell Cycle
R-HSA-69615 G1/S DNA Damage Checkpoints
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-74160 Gene expression (Transcription)
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-69620 Cell Cycle Checkpoints

-  Other Names for This Gene
  Alternate Gene Symbols: CAP20, CDKN1, CDN1A_HUMAN, CIP1, MDA6, NM_078467, NP_510867, P38936, PIC1, Q14010, Q9BUT4, SDI1, WAF1
UCSC ID: uc021yzb.1
RefSeq Accession: NM_078467
Protein: P38936 (aka CDN1A_HUMAN or CDNA_HUMAN)
CCDS: CCDS4824.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_078467.2
exon count: 4CDS single in 3' UTR: no RNA size: 2122
ORF size: 495CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 1289.00frame shift in genome: no % Coverage: 99.25
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.