Description: Homo sapiens chemokine (C-X-C motif) ligand 17 (CXCL17), mRNA. RefSeq Summary (NM_198477): The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr19:42,932,695-42,947,136 Size: 14,442 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr19:42,933,036-42,946,984 Size: 13,949 Coding Exon Count: 4
ID:VCC1_HUMAN DESCRIPTION: RecName: Full=VEGF co-regulated chemokine 1; AltName: Full=C-X-C motif chemokine 17; AltName: Full=Dendritic cell and monocyte chemokine-like protein; Short=DMC; Flags: Precursor; FUNCTION: Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up- regulation. DEVELOPMENTAL STAGE: Detected in fetal lung. INDUCTION: Found to be up-regulated in duodenal mucosa during acute cholera. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL17 entry; URL="http://en.wikipedia.org/wiki/CXCL17";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UXB2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
