Description: Homo sapiens chemokine (C-X-C motif) ligand 2 (CXCL2), mRNA. RefSeq Summary (NM_002089): This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]. Transcript (Including UTRs) Position: hg19 chr4:74,962,754-74,964,997 Size: 2,244 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr4:74,963,473-74,964,837 Size: 1,365 Coding Exon Count: 4
ID:CXCL2_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 2; AltName: Full=Growth-regulated protein beta; Short=Gro-beta; AltName: Full=Macrophage inflammatory protein 2-alpha; Short=MIP2-alpha; Contains: RecName: Full=GRO-beta(5-73); AltName: Full=GRO-beta-T; AltName: Full=Hematopoietic synergistic factor; Short=HSF; AltName: Full=SB-251353; Flags: Precursor; FUNCTION: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells. PHARMACEUTICAL: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL2 entry; URL="http://en.wikipedia.org/wiki/CXCL2";
Leukocyte Count Alexander P Reiner et al. PLoS genetics 2011, Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)., PLoS genetics.
[PubMed 21738479]
sepsis , A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population, Genes Immun 2006.
[PubMed 16421598]
Sepsis|Systemic infection Jesns Villar et al. 2007, A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis., Critical care medicine 35(10) : 2292-7 2007.
[PubMed 17944017]
Association with mortality of severe sepsis
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19875
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.