Human Gene DHX57 (uc002rrd.4)
Description: Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 (DHX57), mRNA.
Transcript (Including UTRs)
Position: hg19 chr2:39,024,876-39,082,394 Size: 57,519 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr2:39,025,441-39,081,377 Size: 55,937 Coding Exon Count: 15
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: Q59G60_HUMAN
DESCRIPTION: SubName: Full=DHX57 protein variant; Flags: Fragment;
SIMILARITY: Contains 1 helicase ATP-binding domain.SIMILARITY: Contains 1 helicase C-terminal domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR002464 - DNA/RNA_helicase_DEAH_CS
IPR011709 - DUF1605
IPR007502 - Helicase-assoc_dom
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
Pfam Domains: PF00271 - Helicase conserved C-terminal domain
PF04408 - Helicase associated domain (HA2)
PF07717 - Oligonucleotide/oligosaccharide-binding (OB)-fold
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases
ModBase Predicted Comparative 3D Structure on Q59G60
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC065278 - Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57, mRNA (cDNA clone IMAGE:6163491), partial cds.AB209249 - Homo sapiens mRNA for DHX57 protein variant protein.BC053623 - Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57, mRNA (cDNA clone IMAGE:6162121), partial cds.AF283512 - Homo sapiens putative DEAH-box RNA/DNA helicase mRNA, complete cds.BC131534 - Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57, mRNA (cDNA clone MGC:141843 IMAGE:40082400), complete cds.BC153875 - Homo sapiens cDNA clone IMAGE:40148186, containing frame-shift errors.BC039270 - Homo sapiens cDNA clone IMAGE:5296135.AK307514 - Homo sapiens cDNA, FLJ97462.AK296739 - Homo sapiens cDNA FLJ56001 partial cds, highly similar to Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-).BC033636 - Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57, mRNA (cDNA clone IMAGE:5578373), partial cds.AF070590 - Homo sapiens clones 24622 and 24623 mRNA sequence.JD299438 - Sequence 280462 from Patent EP1572962.JD495773 - Sequence 476797 from Patent EP1572962.JD275875 - Sequence 256899 from Patent EP1572962.JD335491 - Sequence 316515 from Patent EP1572962.JD135491 - Sequence 116515 from Patent EP1572962.JD475888 - Sequence 456912 from Patent EP1572962.JD099822 - Sequence 80846 from Patent EP1572962.JD309767 - Sequence 290791 from Patent EP1572962.BC060778 - Homo sapiens DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57, mRNA (cDNA clone IMAGE:30338933), complete cds.JD226995 - Sequence 208019 from Patent EP1572962.JD421472 - Sequence 402496 from Patent EP1572962.JD199464 - Sequence 180488 from Patent EP1572962.KJ903558 - Synthetic construct Homo sapiens clone ccsbBroadEn_12952 DHX57 gene, encodes complete protein.
Other Names for This Gene
Alternate Gene Symbols: AB209249, Q59G60, Q59G60_HUMANUCSC ID: uc002rrd.4RefSeq Accession: NM_198963
Protein: Q59G60
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AB209249.1
exon count:
15 CDS single in 3' UTR:
no
RNA size:
3176
ORF size:
2178 CDS single in intron:
no
Alignment % ID:
99.91
txCdsPredict score:
4070.00 frame shift in genome:
no
% Coverage:
91.31
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
yes
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.