Human Gene EIF1AY (uc004fuk.3)
  Description: Homo sapiens eukaryotic translation initiation factor 1A, Y-linked (EIF1AY), mRNA.
RefSeq Summary (NM_004681): This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Transcript (Including UTRs)
   Position: hg19 chrY:22,737,611-22,755,040 Size: 17,430 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chrY:22,737,758-22,754,232 Size: 16,475 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrY:22,737,611-22,755,040)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IF1AY_HUMAN
DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal; Short=eIF-1A Y isoform; AltName: Full=Eukaryotic translation initiation factor 4C; Short=eIF-4C;
FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).
INTERACTION: O60841:EIF5B; NbExp=2; IntAct=EBI-286439, EBI-928530;
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the eIF-1A family.
SIMILARITY: Contains 1 S1-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): EIF1AY
CDC HuGE Published Literature: EIF1AY

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.86 RPKM in Heart - Left Ventricle
Total median expression: 238.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.90147-0.292 Picture PostScript Text
3' UTR -174.50808-0.216 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012340 - NA-bd_OB-fold
IPR016027 - NA-bd_OB-fold-like
IPR006196 - RNA-binding_domain_S1_IF1
IPR001253 - TIF_eIF-1A
IPR018104 - TIF_eIF-1A_CS

Pfam Domains:
PF01176 - Translation initiation factor 1A / IF-1

SCOP Domains:
50249 - Nucleic acid-binding proteins

ModBase Predicted Comparative 3D Structure on O14602
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
    WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Biological Process:
GO:0006412 translation
GO:0006413 translational initiation


-  Descriptions from all associated GenBank mRNAs
  AF000987 - Homo sapiens eIF-1A, Y isoform (EIF1AY) mRNA, complete cds.
JD444325 - Sequence 425349 from Patent EP1572962.
JD383821 - Sequence 364845 from Patent EP1572962.
JD070794 - Sequence 51818 from Patent EP1572962.
JD320729 - Sequence 301753 from Patent EP1572962.
DQ786267 - Homo sapiens clone HLS_IMAGE_305122 mRNA sequence.
BC005248 - Homo sapiens eukaryotic translation initiation factor 1A, Y-linked, mRNA (cDNA clone MGC:12282 IMAGE:3933718), complete cds.
DQ890576 - Synthetic construct clone IMAGE:100003206; FLH164080.01X; RZPDo839C06162D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
DQ893736 - Synthetic construct Homo sapiens clone IMAGE:100008196; FLH164076.01L; RZPDo839C06161D eukaryotic translation initiation factor 1A, Y-linked (EIF1AY) gene, encodes complete protein.
KJ892683 - Synthetic construct Homo sapiens clone ccsbBroadEn_02077 EIF1AY gene, encodes complete protein.
BT007201 - Homo sapiens eukaryotic translation initiation factor 1A, Y chromosome mRNA, complete cds.
AK127664 - Homo sapiens cDNA FLJ45762 fis, clone MESTC2000170.
JD419160 - Sequence 400184 from Patent EP1572962.
JD093517 - Sequence 74541 from Patent EP1572962.
JD327491 - Sequence 308515 from Patent EP1572962.
JD244299 - Sequence 225323 from Patent EP1572962.
JD564120 - Sequence 545144 from Patent EP1572962.
JD501651 - Sequence 482675 from Patent EP1572962.
JD044012 - Sequence 25036 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: IF1AY_HUMAN, NM_004681, NP_004672, O14602, Q9BS77
UCSC ID: uc004fuk.3
RefSeq Accession: NM_004681
Protein: O14602 (aka IF1AY_HUMAN or IF1Y_HUMAN)
CCDS: CCDS14795.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004681.2
exon count: 7CDS single in 3' UTR: no RNA size: 1399
ORF size: 435CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 635.00frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.