Description: Homo sapiens interleukin 5 (colony-stimulating factor, eosinophil) (IL5), mRNA. RefSeq Summary (NM_000879): This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]. Transcript (Including UTRs) Position: hg19 chr5:131,877,136-131,879,214 Size: 2,079 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:131,877,503-131,879,170 Size: 1,668 Coding Exon Count: 4
asthma atopy Kabesch, M. et al. 2007, Polymorphisms in eosinophil pathway genes, asthma and atopy, Allergy 2007 62(4) 423-8.
[PubMed 17362254]
IL-5 C-746T influenced atopic outcomes and showed evidence for gene by gene interaction. No significant associations were found with all other tested polymorphisms in the eosinophil regulation pathway after correction for multiple testing.
dermatitis and eczema Namkung, J. H. et al. 2007, IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans, Allergy 2007 62(8) 934-42.
[PubMed 17620072]
We found that the rs2522411SNP and the haplotype T-A in the IL-5 gene and the serum IL-5 levels were strongly associated with the allergic type of AD, but not with the nonallergic type of AD. The association of the rs6771148SNP and the haplotype T-C-T in the IL5RA gene with the blood eosinophil counts and the serum ECP levels indicates that the IL5RA gene ha
Inflammation|Premature Birth Velez DR et al. 2008, Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants., PloS one 3(9) : e3283 2008.
[PubMed 18818748]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05113
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
DQ655971 - Homo sapiens clone UGL8g04, mRNA sequence. BC069137 - Homo sapiens cDNA clone IMAGE:7216996, containing frame-shift errors. E01639 - cDNA encoding human B cell differentiation Factor. X04688 - Human mRNA for T-cell replacing factor (interleukin-5). X12705 - H.sapiens mRNA for B cell differentiation factor I. JD047365 - Sequence 28389 from Patent EP1572962. JD069004 - Sequence 50028 from Patent EP1572962. JD062579 - Sequence 43603 from Patent EP1572962. BC066279 - Homo sapiens cDNA clone IMAGE:6971768, containing frame-shift errors. BC066280 - Homo sapiens cDNA clone IMAGE:6971769, containing frame-shift errors. BC066281 - Homo sapiens cDNA clone IMAGE:6971770, containing frame-shift errors. BC066282 - Homo sapiens interleukin 5 (colony-stimulating factor, eosinophil), mRNA (cDNA clone MGC:79409 IMAGE:6971771), complete cds. FU768456 - Short interference ribonucleic acids for treating allergic diseases. KJ897045 - Synthetic construct Homo sapiens clone ccsbBroadEn_06439 IL5 gene, encodes complete protein. AB591005 - Synthetic construct DNA, clone: pFN21AB6718, Homo sapiens IL5 gene for interleukin 5, without stop codon, in Flexi system. FU768455 - Short interference ribonucleic acids for treating allergic diseases. DQ655974 - Homo sapiens clone UGL8e03, mRNA sequence. FU768454 - Short interference ribonucleic acids for treating allergic diseases. JD208142 - Sequence 189166 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04630 - Jak-STAT signaling pathway hsa04640 - Hematopoietic cell lineage hsa04660 - T cell receptor signaling pathway hsa04664 - Fc epsilon RI signaling pathway hsa04672 - Intestinal immune network for IgA production hsa05310 - Asthma hsa05320 - Autoimmune thyroid disease hsa05330 - Allograft rejection
BioCarta from NCI Cancer Genome Anatomy Project h_nktPathway - Selective expression of chemokine receptors during T-cell polarization h_stemPathway - Regulation of hematopoiesis by cytokines h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy h_il5Pathway - IL 5 Signaling Pathway h_inflamPathway - Cytokines and Inflammatory Response h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development h_cytokinePathway - Cytokine Network
Reactome (by CSHL, EBI, and GO)
Protein P05113 (Reactome details) participates in the following event(s):
R-HSA-913446 Interleukin-5 is a homodimer R-HSA-913456 Interleukin-5 receptor alpha subunit binds Interleukin-5 R-HSA-913370 Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 R-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chain R-HSA-909738 SHP1 and SHP2 bind the common beta chain R-HSA-879907 Tyrosine kinases phosphorylate the receptor R-HSA-879930 STAT5 is recruited by JAK2 R-HSA-879910 JAK2 is phosphorylated, activated R-HSA-921155 p-STAT5 dissociates from the receptor complex R-HSA-913451 IL3RB is phosphorylated on Ser-585 R-HSA-912757 p-S585-IL3RB binds 14-3-3 proteins R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylated R-HSA-914036 SHP1 and SHP2 dephosphorylate Y628 of IL3RB R-HSA-879909 Activation of STAT5a/b by JAK2 R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1 R-HSA-913374 Phosphorylated SHC1 recruits SHIP R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2 R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System R-HSA-912526 Interleukin receptor SHC signaling R-HSA-451927 Interleukin-2 family signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction
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