ID:MREG_HUMAN DESCRIPTION: RecName: Full=Melanoregulin; AltName: Full=Dilute suppressor protein homolog; FUNCTION: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). SUBUNIT: Interacts with PRPH2 (By similarity). SUBCELLULAR LOCATION: Apical cell membrane; Peripheral membrane protein (By similarity). Note=Localizes to the inner segment and basal outer segment of rods in the retina (By similarity). TISSUE SPECIFICITY: Expressed in photoreceptor cells (at protein level). SIMILARITY: Belongs to the melanoregulin family.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MREG CDC HuGE Published Literature: MREG Positive Disease Associations: Albuminuria
, Alcoholism Related Studies:
Albuminuria Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903292]
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
Alcoholism Jens Treutlein et al. Archives of general psychiatry 2009, Genome-wide association study of alcohol dependence., Archives of general psychiatry.
[PubMed 19581569]
This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence. Further independent studies are required to confirm these findings.
Alcoholism Josef Frank et al. Addiction biology 2012, Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster., Addiction biology.
[PubMed 22004471]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N565
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
