Description: Homo sapiens neuronal differentiation 2 (NEUROD2), mRNA. RefSeq Summary (NM_006160): This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:37,760,021-37,764,175 Size: 4,155 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr17:37,761,704-37,762,852 Size: 1,149 Coding Exon Count: 1
ID:NDF2_HUMAN DESCRIPTION: RecName: Full=Neurogenic differentiation factor 2; Short=NeuroD2; AltName: Full=Class A basic helix-loop-helix protein 1; Short=bHLHa1; AltName: Full=NeuroD-related factor; Short=NDRF; FUNCTION: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). SUBUNIT: Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation require dimerization with another bHLH protein (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: The C-terminus region is necessary for depolarization- induced and calcium-dependent transcription activation (By similarity). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15784
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0070888 E-box binding
Biological Process: GO:0001662 behavioral fear response GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0008306 associative learning GO:0016567 protein ubiquitination GO:0021695 cerebellar cortex development GO:0030154 cell differentiation GO:0031915 positive regulation of synaptic plasticity GO:0045664 regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048666 neuron development GO:0050850 positive regulation of calcium-mediated signaling GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0071257 cellular response to electrical stimulus GO:0071277 cellular response to calcium ion GO:0090128 regulation of synapse maturation GO:0090129 positive regulation of synapse maturation GO:1903507 negative regulation of nucleic acid-templated transcription GO:2000297 negative regulation of synapse maturation
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