Acquired Immunodeficiency Syndrome Jennifer L Troyer et al. The Journal of infectious diseases 2011, Genome-wide association study implicates PARD3B-based AIDS restriction., The Journal of infectious diseases.
[PubMed 21502085]
These observations suggest a potential unsuspected pathway of host genetic influence on the dynamics of AIDS progression.
Body Height Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00595 - PDZ domain (Also known as DHR or GLGF) PF12053 - N-terminal of Par3 and HAL proteins PF13180 - PDZ domain
ModBase Predicted Comparative 3D Structure on Q8TEW8-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.