Description: Homo sapiens poly (ADP-ribose) polymerase family, member 10 (PARP10), mRNA. RefSeq Summary (NM_032789): Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr8:145,051,320-145,060,635 Size: 9,316 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr8:145,051,652-145,060,527 Size: 8,876 Coding Exon Count: 11
ID:PAR10_HUMAN DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 10; Short=PARP-10; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 10; Short=ARTD10; FUNCTION: May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. SUBUNIT: Interacts with MYC. SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase. TISSUE SPECIFICITY: Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon. PTM: Stimulated through its phosphorylation by CDK2. Acquires CDK- dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. SIMILARITY: Contains 1 PARP catalytic domain. SEQUENCE CAUTION: Sequence=BAC11498.1; Type=Frameshift; Positions=965;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53GL7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006471 protein ADP-ribosylation GO:0010629 negative regulation of gene expression GO:0010847 regulation of chromatin assembly GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0045071 negative regulation of viral genome replication GO:0048147 negative regulation of fibroblast proliferation GO:0070212 protein poly-ADP-ribosylation GO:0070213 protein auto-ADP-ribosylation GO:1900045 negative regulation of protein K63-linked ubiquitination
US Server
