Human Gene PPP1R7 (uc002wat.1)
  Description: Homo sapiens protein phosphatase 1, regulatory subunit 7 (PPP1R7), mRNA.
RefSeq Summary (NM_002712): This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Transcript (Including UTRs)
   Position: hg19 chr2:242,089,902-242,122,439 Size: 32,538 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr2:242,089,911-242,122,238 Size: 32,328 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:242,089,902-242,122,439)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PP1R7_HUMAN
DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 7; AltName: Full=Protein phosphatase 1 regulatory subunit 22;
FUNCTION: Regulatory subunit of protein phosphatase 1 (By similarity).
SUBUNIT: Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the SDS22 family.
SIMILARITY: Contains 11 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PPP1R7
CDC HuGE Published Literature: PPP1R7
Positive Disease Associations: Forced Vital Capacity
Related Studies:
  1. Forced Vital Capacity
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 104.91 RPKM in Testis
Total median expression: 1400.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -48.40201-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies
IPR003603 - U2A'_phosphoprotein32A_C

Pfam Domains:
PF00560 - Leucine Rich Repeat
PF12799 - Leucine Rich repeats (2 copies)
PF13855 - Leucine rich repeat
PF14580 - Leucine-rich repeat

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q15435
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGDEnsembl WormBaseSGD
 Protein SequenceProtein Sequence Protein SequenceProtein Sequence
 AlignmentAlignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0019888 protein phosphatase regulator activity
GO:0030234 enzyme regulator activity

Biological Process:
GO:0007059 chromosome segregation
GO:0008150 biological_process
GO:0035307 positive regulation of protein dephosphorylation
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0050790 regulation of catalytic activity

Cellular Component:
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK308015 - Homo sapiens cDNA, FLJ97963.
BC051689 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 7, mRNA (cDNA clone IMAGE:5180137), with apparent retained intron.
AK294043 - Homo sapiens cDNA FLJ57350 complete cds, highly similar to Protein phosphatase 1 regulatory subunit 7.
BC013001 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 7, mRNA (cDNA clone MGC:3671 IMAGE:3528281), complete cds.
BC000910 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 7, mRNA (cDNA clone MGC:5224 IMAGE:2985840), complete cds.
HM005623 - Homo sapiens clone HTL-S-210a testis secretory sperm-binding protein Li 210a mRNA, complete cds.
Z50749 - H.sapiens sds22-like mRNA.
BC012397 - Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 7, mRNA (cDNA clone MGC:9803 IMAGE:3858906), complete cds.
AB385583 - Synthetic construct DNA, clone: pF1KB9509, Homo sapiens PPP1R7 gene for protein phosphatase 1 regulatory subunit 7, complete cds, without stop codon, in Flexi system.
BT007296 - Homo sapiens protein phosphatase 1, regulatory subunit 7 mRNA, complete cds.
KJ901656 - Synthetic construct Homo sapiens clone ccsbBroadEn_11050 PPP1R7 gene, encodes complete protein.
BT020134 - Homo sapiens protein phosphatase 1, regulatory subunit 7 mRNA, complete cds.
JD023838 - Sequence 4862 from Patent EP1572962.
JD025514 - Sequence 6538 from Patent EP1572962.
JD030953 - Sequence 11977 from Patent EP1572962.
JD487617 - Sequence 468641 from Patent EP1572962.
JD062035 - Sequence 43059 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DFD4, NM_002712, NP_002703, PP1R7_HUMAN, Q15435, Q9UQE5, Q9UQE6, Q9Y6K4, SDS22
UCSC ID: uc002wat.1
RefSeq Accession: NM_002712
Protein: Q15435 (aka PP1R7_HUMAN)
CCDS: CCDS2546.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002712.1
exon count: 10CDS single in 3' UTR: no RNA size: 1299
ORF size: 1083CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 2338.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.