ID:PSMG2_HUMAN DESCRIPTION: RecName: Full=Proteasome assembly chaperone 2; Short=PAC-2; AltName: Full=Hepatocellular carcinoma-susceptibility protein 3; AltName: Full=Tumor necrosis factor superfamily member 5-induced protein 1; FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. SUBUNIT: Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. PTM: Degraded by the proteasome upon completion of 20S proteasome maturation. SIMILARITY: Belongs to the PSMG2 family.
Crohn Disease Miles Parkes et al. Nature genetics 2007, Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility., Nature genetics.
[PubMed 17554261]
Crohn Disease Paul R Burton et al. Nature 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls., Nature.
[PubMed 17554300]
Crohn Disease Jeffrey C Barrett et al. Nature genetics 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease., Nature genetics.
[PubMed 18587394]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969U7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
