ID:HACD3_HUMAN DESCRIPTION: RecName: Full=Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3; EC=4.2.1.134; AltName: Full=3-hydroxyacyl-CoA dehydratase 3; Short=HACD3; AltName: Full=Butyrate-induced protein 1; Short=B-ind1; Short=hB-ind1; AltName: Full=Protein tyrosine phosphatase-like protein PTPLAD1; AltName: Full=Protein-tyrosine phosphatase-like A domain-containing protein 1; FUNCTION: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression. CATALYTIC ACTIVITY: A very-long-chain (3R)-3-hydroxyacyl-[acyl- carrier protein] = a very-long-chain trans-2,3-dehydroacyl-[acyl- carrier protein] + H(2)O. SUBUNIT: Interacts with the condensation enzymes of the ELOVL family. Interacts with RAC1. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. INDUCTION: By AKAP12 and histone deacetylase inhibitors such as sodium butyrate. SIMILARITY: Belongs to the very long-chain fatty acids dehydratase HACD family. SIMILARITY: Contains 1 CS domain. SEQUENCE CAUTION: Sequence=AAF29085.1; Type=Frameshift; Positions=356; Sequence=BAC11249.1; Type=Frameshift; Positions=359;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P035
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0007264 small GTPase mediated signal transduction GO:0007266 Rho protein signal transduction GO:0016601 Rac protein signal transduction GO:0030148 sphingolipid biosynthetic process GO:0030497 fatty acid elongation GO:0042761 very long-chain fatty acid biosynthetic process GO:0043547 positive regulation of GTPase activity GO:0045070 positive regulation of viral genome replication GO:0046726 positive regulation by virus of viral protein levels in host cell
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