Human Gene RPL10 (uc004fkm.2)
  Description: Homo sapiens ribosomal protein L10 (RPL10), transcript variant 1, mRNA.
RefSeq Summary (NM_006013): This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Transcript (Including UTRs)
   Position: hg19 chrX:153,626,571-153,630,680 Size: 4,110 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chrX:153,626,861-153,629,195 Size: 2,335 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:153,626,571-153,630,680)mRNA (may differ from genome)Protein (214 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RL10_HUMAN
DESCRIPTION: RecName: Full=60S ribosomal protein L10; AltName: Full=Laminin receptor homolog; AltName: Full=Protein QM; AltName: Full=Tumor suppressor QM;
SUBUNIT: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
DEVELOPMENTAL STAGE: Down-regulated during adipocyte, kidney, and heart differentiation.
DISEASE: Defects in RPL10 are a cause of susceptibility to autism X-linked type 5 (AUTSX5) [MIM:300847]. A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note=RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
SIMILARITY: Belongs to the ribosomal protein L10e family.
SEQUENCE CAUTION: Sequence=AAB22173.1; Type=Frameshift; Positions=124; Sequence=CAM45852.1; Type=Erroneous gene model prediction; Sequence=CAM45853.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RPL10
CDC HuGE Published Literature: RPL10

-  MalaCards Disease Associations
  MalaCards Gene Search: RPL10
Diseases sorted by gene-association score: autism x-linked 5* (904), mental retardation, x-linked, syndromic, 35* (900), x-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome* (350), x-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome* (350), autism spectrum disorder* (46), pervasive developmental disorder (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001280 Atrazine
  • D013749 Tetrachlorodibenzodioxin
  • C019499 2-nitrofluorene
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C009505 4,4'-diaminodiphenylmethane
  • C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D016604 Aflatoxin B1
  • D000643 Ammonium Chloride
  • C099555 CD 437
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1536.27 RPKM in Ovary
Total median expression: 28021.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.80188-0.377 Picture PostScript Text
3' UTR -538.871485-0.363 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001197 - Ribosomal_L10e
IPR016180 - Ribosomal_L10e/L16
IPR018255 - Ribosomal_L10e_CS

Pfam Domains:
PF00252 - Ribosomal protein L16p/L10e

SCOP Domains:
54686 - Ribosomal protein L10e

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2PA2 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P27635
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity

Biological Process:
GO:0000027 ribosomal large subunit assembly
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0007275 multicellular organism development
GO:0043066 negative regulation of apoptotic process
GO:1990403 embryonic brain development

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0032991 macromolecular complex
GO:0005790 smooth endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  LF385326 - JP 2014500723-A/192829: Polycomb-Associated Non-Coding RNAs.
LF380850 - JP 2014500723-A/188353: Polycomb-Associated Non-Coding RNAs.
LF211539 - JP 2014500723-A/19042: Polycomb-Associated Non-Coding RNAs.
LF214071 - JP 2014500723-A/21574: Polycomb-Associated Non-Coding RNAs.
D28410 - Homo sapiens mRNA for QM protein, 5'UTR region.
AK130582 - Homo sapiens cDNA FLJ27072 fis, clone SPL01818, highly similar to 60S ribosomal protein L10.
M64241 - Human Wilm's tumor-related protein (QM) mRNA, complete cds.
AK026568 - Homo sapiens cDNA: FLJ22915 fis, clone KAT06354, highly similar to HUMQM Human Wilm's tumor-related protein (QM) mRNA.
AK223309 - Homo sapiens mRNA for ribosomal protein L10 variant, clone: TMS00528.
AK225705 - Homo sapiens mRNA for ribosomal protein L10 variant, clone: TMS00528.
AK307511 - Homo sapiens cDNA, FLJ97459.
BC026276 - Homo sapiens ribosomal protein L10, mRNA (cDNA clone MGC:23823 IMAGE:4276627), complete cds.
BX647954 - Homo sapiens mRNA; cDNA DKFZp686J1851 (from clone DKFZp686J1851).
AK027197 - Homo sapiens cDNA: FLJ23544 fis, clone LNG08336.
JD394085 - Sequence 375109 from Patent EP1572962.
JD394084 - Sequence 375108 from Patent EP1572962.
BC095425 - Homo sapiens ribosomal protein L10, mRNA (cDNA clone IMAGE:30709458).
AF218023 - Homo sapiens clone PP5910 unknown mRNA.
BC003358 - Homo sapiens ribosomal protein L10, mRNA (cDNA clone MGC:5189 IMAGE:2900175), complete cds.
JD020744 - Sequence 1768 from Patent EP1572962.
BC071918 - Homo sapiens ribosomal protein L10, mRNA (cDNA clone MGC:88600 IMAGE:6731213), complete cds.
S35960 - laminin receptor homolog {3' region} [human, mRNA Partial, 739 nt].
M73791 - Human novel gene mRNA, complete cds.
BC063422 - Homo sapiens cDNA clone IMAGE:5219540, with apparent retained intron.
AF486812 - Homo sapiens ribosomal protein L10 (QM) mRNA, complete cds.
AB528224 - Synthetic construct DNA, clone: pF1KE0134, Homo sapiens RPL10 gene for ribosomal protein L10, without stop codon, in Flexi system.
AM393337 - Synthetic construct Homo sapiens clone IMAGE:100002067 for hypothetical protein (RPL10 gene).
CR456797 - Homo sapiens full open reading frame cDNA clone RZPDo834B0816D for gene RPL10, ribosomal protein L10; complete cds, incl. stopcodon.
CR542069 - Homo sapiens full open reading frame cDNA clone RZPDo834H0636D for gene RPL10, ribosomal protein L10; complete cds, without stopcodon.
KJ534934 - Homo sapiens clone RPL10_iso-A_adult-A01 ribosomal protein L10 isoform A (RPL10) mRNA, partial cds, alternatively spliced.
KJ534979 - Homo sapiens clone RPL10_iso-B_adult-A04 ribosomal protein L10 isoform B (RPL10) mRNA, partial cds, alternatively spliced.
DQ369703 - Homo sapiens cell-line MDAMB 231 QM protein mRNA, complete cds.
DQ369704 - Homo sapiens clone Ove-202Ser QM protein isoform 2 mRNA, complete cds.
DQ369705 - Homo sapiens cell-line OVCAR QM protein mRNA, complete cds.
DQ369706 - Homo sapiens cell-line MCF-7 QM protein mRNA, complete cds.
DQ369707 - Homo sapiens cell-line T46D QM protein mRNA, complete cds.
DQ369708 - Homo sapiens cell-line PANC1 QM protein mRNA, complete cds.
DQ369709 - Homo sapiens cell-line PANC28 QM protein mRNA, complete cds.
DQ369710 - Homo sapiens cell-line HPAC QM protein mRNA, complete cds.
DQ369711 - Homo sapiens cell-line PI QM protein mRNA, complete cds.
DQ369712 - Homo sapiens cell-line BxPC3 QM protein mRNA, complete cds.
DQ369713 - Homo sapiens clone Ove-203Asn QM protein isoform 1 mRNA, complete cds.
DQ369714 - Homo sapiens cell-line PC3 QM protein mRNA, complete cds.
DQ369715 - Homo sapiens cell-line FG (Colo357 F.S) QM protein mRNA, complete cds.
DQ369716 - Homo sapiens cell-line BT-20 QM protein mRNA, complete cds.
S35959 - laminin receptor homolog clone A {5' region} [human, mRNA Partial, 306 nt].
JD028302 - Sequence 9326 from Patent EP1572962.
AY927570 - Homo sapiens mRNA sequence.
AB019572 - Homo sapiens mRNA expressed only in placental villi, clone SMAP26.
LF380851 - JP 2014500723-A/188354: Polycomb-Associated Non-Coding RNAs.
LF380852 - JP 2014500723-A/188355: Polycomb-Associated Non-Coding RNAs.
JD023104 - Sequence 4128 from Patent EP1572962.
JD028594 - Sequence 9618 from Patent EP1572962.
LF380854 - JP 2014500723-A/188357: Polycomb-Associated Non-Coding RNAs.
DQ570720 - Homo sapiens piRNA piR-30832, complete sequence.
LF380855 - JP 2014500723-A/188358: Polycomb-Associated Non-Coding RNAs.
JD019721 - Sequence 745 from Patent EP1572962.
JD026433 - Sequence 7457 from Patent EP1572962.
LF380856 - JP 2014500723-A/188359: Polycomb-Associated Non-Coding RNAs.
LF372555 - JP 2014500723-A/180058: Polycomb-Associated Non-Coding RNAs.
LF325738 - JP 2014500723-A/133241: Polycomb-Associated Non-Coding RNAs.
JD408695 - Sequence 389719 from Patent EP1572962.
JD164058 - Sequence 145082 from Patent EP1572962.
JD513810 - Sequence 494834 from Patent EP1572962.
JD179006 - Sequence 160030 from Patent EP1572962.
JD541740 - Sequence 522764 from Patent EP1572962.
JD433118 - Sequence 414142 from Patent EP1572962.
JD186660 - Sequence 167684 from Patent EP1572962.
JD369781 - Sequence 350805 from Patent EP1572962.
JD038581 - Sequence 19605 from Patent EP1572962.
JD310455 - Sequence 291479 from Patent EP1572962.
JD107987 - Sequence 89011 from Patent EP1572962.
JD283032 - Sequence 264056 from Patent EP1572962.
JD486617 - Sequence 467641 from Patent EP1572962.
JD365516 - Sequence 346540 from Patent EP1572962.
BC018570 - Homo sapiens ribosomal protein L10, mRNA (cDNA clone IMAGE:3448806).
JD565059 - Sequence 546083 from Patent EP1572962.
JD297803 - Sequence 278827 from Patent EP1572962.
JD555411 - Sequence 536435 from Patent EP1572962.
JD487981 - Sequence 469005 from Patent EP1572962.
JD470080 - Sequence 451104 from Patent EP1572962.
JD430013 - Sequence 411037 from Patent EP1572962.
JD262944 - Sequence 243968 from Patent EP1572962.
JD512445 - Sequence 493469 from Patent EP1572962.
JD543781 - Sequence 524805 from Patent EP1572962.
JD411226 - Sequence 392250 from Patent EP1572962.
JD479904 - Sequence 460928 from Patent EP1572962.
JD288063 - Sequence 269087 from Patent EP1572962.
MA620903 - JP 2018138019-A/192829: Polycomb-Associated Non-Coding RNAs.
MA449648 - JP 2018138019-A/21574: Polycomb-Associated Non-Coding RNAs.
MA608132 - JP 2018138019-A/180058: Polycomb-Associated Non-Coding RNAs.
MA561315 - JP 2018138019-A/133241: Polycomb-Associated Non-Coding RNAs.
MA616427 - JP 2018138019-A/188353: Polycomb-Associated Non-Coding RNAs.
MA447116 - JP 2018138019-A/19042: Polycomb-Associated Non-Coding RNAs.
MA616428 - JP 2018138019-A/188354: Polycomb-Associated Non-Coding RNAs.
MA616429 - JP 2018138019-A/188355: Polycomb-Associated Non-Coding RNAs.
MA616431 - JP 2018138019-A/188357: Polycomb-Associated Non-Coding RNAs.
MA616432 - JP 2018138019-A/188358: Polycomb-Associated Non-Coding RNAs.
MA616433 - JP 2018138019-A/188359: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03010 - Ribosome

Reactome (by CSHL, EBI, and GO)

Protein P27635 (Reactome details) participates in the following event(s):

R-HSA-72672 The 60S subunit joins the translation initiation complex
R-HSA-156826 Dissociation of L13a from the 60s ribosomal subunit
R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome
R-HSA-72671 eIF5B:GTP is hydrolyzed and released
R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site
R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction
R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA
R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex
R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex
R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
R-HSA-156923 Hydrolysis of eEF1A:GTP
R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC
R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)
R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-156827 L13a-mediated translation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-156902 Peptide chain elongation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-72766 Translation
R-HSA-376176 Signaling by ROBO receptors
R-HSA-192823 Viral mRNA Translation
R-HSA-72312 rRNA processing
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-8953854 Metabolism of RNA
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1266738 Developmental Biology
R-HSA-168255 Influenza Life Cycle
R-HSA-1430728 Metabolism
R-HSA-168254 Influenza Infection
R-HSA-5663205 Infectious disease
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A3KQT0, D3DWW6, DXS648E, NM_006013, NP_006004, P27635, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5, QM, RL10_HUMAN
UCSC ID: uc004fkm.2
RefSeq Accession: NM_006013
Protein: P27635 (aka RL10_HUMAN)
CCDS: CCDS14746.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_006013.3
exon count: 7CDS single in 3' UTR: no RNA size: 2335
ORF size: 645CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1361.00frame shift in genome: no % Coverage: 99.27
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.