Description: Homo sapiens toll-like receptor 7 (TLR7), mRNA. RefSeq Summary (NM_016562): The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:12,885,202-12,908,480 Size: 23,279 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chrX:12,885,698-12,906,777 Size: 21,080 Coding Exon Count: 2
ID:TLR7_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 7; Flags: Precursor; FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). TISSUE SPECIFICITY: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 27 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain.
fibrosis hepatitis C, chronic Schott, E. et al. 2007, A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection, J Hepatol 2007.
[PubMed 17512627]
This is the first analysis of TLR7 SNPs in patients with chronic HCV-infection. Our data suggest that the c.1-120G TLR7 allele offers protection from the development of inflammation and fibrosis in male patients with chronic HCV-infection.
Genetic Diseases, X-Linked|Lupus Erythematosus, Systemic|Systemic lupus erythematosus Shen N et al. 2010, Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus., PNAS 107(36) : 15838-43 2010.
[PubMed 20733074]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q9NYK1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK313858 - Homo sapiens cDNA, FLJ94489, Homo sapiens toll-like receptor 7 (TLR7), mRNA. BC033651 - Homo sapiens toll-like receptor 7, mRNA (cDNA clone MGC:45096 IMAGE:5582912), complete cds. AF240467 - Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds. AF245702 - Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds. AY358292 - Homo sapiens clone DNA40021 TLR7 (UNQ248) mRNA, complete cds. JD250016 - Sequence 231040 from Patent EP1572962. JD378392 - Sequence 359416 from Patent EP1572962. JD040861 - Sequence 21885 from Patent EP1572962. CU689684 - Synthetic construct Homo sapiens gateway clone IMAGE:100020487 5' read TLR7 mRNA. DQ894457 - Synthetic construct Homo sapiens clone IMAGE:100008917; FLH170597.01L; RZPDo839H0397D toll-like receptor 7 (TLR7) gene, encodes complete protein. KJ898877 - Synthetic construct Homo sapiens clone ccsbBroadEn_08271 TLR7 gene, encodes complete protein. KR710902 - Synthetic construct Homo sapiens clone CCSBHm_00018089 TLR7 (TLR7) mRNA, encodes complete protein. AB445659 - Homo sapiens TLR7 mRNA for toll-like receptor 7, complete cds. DQ891269 - Synthetic construct clone IMAGE:100003899; FLH170601.01X; RZPDo839H0398D toll-like receptor 7 (TLR7) gene, encodes complete protein. JD515585 - Sequence 496609 from Patent EP1572962. JD208722 - Sequence 189746 from Patent EP1572962. JD430349 - Sequence 411373 from Patent EP1572962. JD529477 - Sequence 510501 from Patent EP1572962. JD169775 - Sequence 150799 from Patent EP1572962. JD306415 - Sequence 287439 from Patent EP1572962. JD055279 - Sequence 36303 from Patent EP1572962. JD125782 - Sequence 106806 from Patent EP1572962. JD325463 - Sequence 306487 from Patent EP1572962. JD152447 - Sequence 133471 from Patent EP1572962. JD408224 - Sequence 389248 from Patent EP1572962. JD408223 - Sequence 389247 from Patent EP1572962. JD393316 - Sequence 374340 from Patent EP1572962. JD277359 - Sequence 258383 from Patent EP1572962. JD401803 - Sequence 382827 from Patent EP1572962. JD481884 - Sequence 462908 from Patent EP1572962. JD481886 - Sequence 462910 from Patent EP1572962. JD481885 - Sequence 462909 from Patent EP1572962. JD446717 - Sequence 427741 from Patent EP1572962. JD102807 - Sequence 83831 from Patent EP1572962. JD062791 - Sequence 43815 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04620 - Toll-like receptor signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_tollPathway - Toll-Like Receptor Pathway h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development
Reactome (by CSHL, EBI, and GO)
Protein Q9NYK1 (Reactome details) participates in the following event(s):
R-HSA-1678920 TLR processing at low pH R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex R-HSA-167983 Ligand binds to TLR7 or TLR8 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
US Server
