Human Gene WDR26 (uc001hop.4)
Description: Homo sapiens WD repeat domain 26 (WDR26), transcript variant 1, mRNA.
RefSeq Summary (NM_025160): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
Position: hg19 chr1:224,572,845-224,622,001 Size: 49,157 Total Exon Count: 14 Strand: -
Coding Region
Position: hg19 chr1:224,577,537-224,621,807 Size: 44,271 Coding Exon Count: 14
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: WDR26_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 26; AltName: Full=CUL4- and DDB1-associated WDR protein 2; AltName: Full=Myocardial ischemic preconditioning up-regulated protein 2;
FUNCTION: May be involved in MAPK pathways.SUBUNIT: Interacts with DDB1-CUL4A/B E3 ligase complexes.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Broadly expressed, with highest levels in heart and skeletal muscle.SIMILARITY: Contains 1 CTLH domain.SIMILARITY: Contains 1 LisH domain.SIMILARITY: Contains 6 WD repeats.SEQUENCE CAUTION: Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006595 - CTLH_C
IPR006594 - LisH_dimerisation
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom
Pfam Domains: PF00400 - WD domain, G-beta repeat
SCOP Domains: 50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain
ModBase Predicted Comparative 3D Structure on Q9H7D7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK023023 - Homo sapiens cDNA FLJ12961 fis, clone NT2RP2005645.AY221751 - Homo sapiens myocardial ischemic preconditioning upregulated protein 2 (MIP2) mRNA, complete cds.AB209887 - Homo sapiens mRNA for WD repeat domain 26 variant protein.BC041978 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:5303050).AK027236 - Homo sapiens cDNA: FLJ23583 fis, clone LNG13775.BC063817 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:6502986), partial cds.BC031471 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:3880754), partial cds.AY304473 - Homo sapiens WD40 repeat protein 26 (WDR26) mRNA, complete cds.JD385656 - Sequence 366680 from Patent EP1572962.JD344308 - Sequence 325332 from Patent EP1572962.JD171494 - Sequence 152518 from Patent EP1572962.JD309590 - Sequence 290614 from Patent EP1572962.JD391902 - Sequence 372926 from Patent EP1572962.JD243461 - Sequence 224485 from Patent EP1572962.JD273243 - Sequence 254267 from Patent EP1572962.JD427219 - Sequence 408243 from Patent EP1572962.JD331704 - Sequence 312728 from Patent EP1572962.JD248863 - Sequence 229887 from Patent EP1572962.JD565889 - Sequence 546913 from Patent EP1572962.JD284226 - Sequence 265250 from Patent EP1572962.JD299046 - Sequence 280070 from Patent EP1572962.JD303590 - Sequence 284614 from Patent EP1572962.JD052911 - Sequence 33935 from Patent EP1572962.JD363740 - Sequence 344764 from Patent EP1572962.JD502887 - Sequence 483911 from Patent EP1572962.EF011612 - Homo sapiens CDW2/WDR26 mRNA, complete cds.BC052301 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone MGC:59723 IMAGE:6420398), complete cds.BC034498 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:4831010), partial cds.AK024669 - Homo sapiens cDNA: FLJ21016 fis, clone CAE05735.AK225061 - Homo sapiens mRNA for WD repeat domain 26 variant, clone: CAE05735.AK299230 - Homo sapiens cDNA FLJ56418 complete cds, highly similar to WD repeat protein 26.JD538596 - Sequence 519620 from Patent EP1572962.JD484539 - Sequence 465563 from Patent EP1572962.JD314000 - Sequence 295024 from Patent EP1572962.AB385130 - Synthetic construct DNA, clone: pF1KB5596, Homo sapiens WDR26 gene for WD repeat protein 26, complete cds, without stop codon, in Flexi system.AK307909 - Homo sapiens cDNA, FLJ97857.AB586698 - Homo sapiens mRNA, IgA nephropathy-related cDNA 4.AF130049 - Homo sapiens clone FLB3411 PRO0852 mRNA, complete cds.
Other Names for This Gene
Alternate Gene Symbols: A0MNN3, CDW2, MIP2, NM_025160, NP_079436, PRO0852, Q4G100, Q59EC4, Q5GLZ9, Q86UY4, Q9H3C2, Q9H7D7, WDR26_HUMANUCSC ID: uc001hop.4RefSeq Accession: NM_025160
Protein: Q9H7D7
(aka WDR26_HUMAN or WD26_HUMAN)
CCDS: CCDS31037.2
GeneReviews for This Gene
GeneReviews article(s) related to gene WDR26:wdr26-id (WDR26-Related Intellectual Disability)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_025160.6
exon count:
14 CDS single in 3' UTR:
no
RNA size:
6884
ORF size:
1986 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3985.00 frame shift in genome:
no
% Coverage:
99.83
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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