Human Gene WDR26 (uc001hop.4)
  Description: Homo sapiens WD repeat domain 26 (WDR26), transcript variant 1, mRNA.
RefSeq Summary (NM_025160): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:224,572,845-224,622,001 Size: 49,157 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr1:224,577,537-224,621,807 Size: 44,271 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:224,572,845-224,622,001)mRNA (may differ from genome)Protein (661 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WDR26_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 26; AltName: Full=CUL4- and DDB1-associated WDR protein 2; AltName: Full=Myocardial ischemic preconditioning up-regulated protein 2;
FUNCTION: May be involved in MAPK pathways.
SUBUNIT: Interacts with DDB1-CUL4A/B E3 ligase complexes.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Broadly expressed, with highest levels in heart and skeletal muscle.
SIMILARITY: Contains 1 CTLH domain.
SIMILARITY: Contains 1 LisH domain.
SIMILARITY: Contains 6 WD repeats.
SEQUENCE CAUTION: Sequence=AAG35477.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH52301.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH63817.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO67709.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ74770.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABK41102.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14955.1; Type=Erroneous termination; Positions=274; Note=Translated as Lys; Sequence=BAD93124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): WDR26
CDC HuGE Published Literature: WDR26
Positive Disease Associations: Breath Tests
Related Studies:
  1. Breath Tests
    , , . [PubMed 0]
  2. Breath Tests
    , , . [PubMed 0]
  3. Breath Tests
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: WDR26
Diseases sorted by gene-association score: skraban-deardorff syndrome* (900), klebsiella infection (17), chromosome 1q41-q42 deletion syndrome (10)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.57 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 861.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.60194-0.431 Picture PostScript Text
3' UTR -1197.944692-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006595 - CTLH_C
IPR006594 - LisH_dimerisation
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - Dipeptidyl peptidase IV/CD26, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q9H7D7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK023023 - Homo sapiens cDNA FLJ12961 fis, clone NT2RP2005645.
AY221751 - Homo sapiens myocardial ischemic preconditioning upregulated protein 2 (MIP2) mRNA, complete cds.
AB209887 - Homo sapiens mRNA for WD repeat domain 26 variant protein.
BC041978 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:5303050).
AK027236 - Homo sapiens cDNA: FLJ23583 fis, clone LNG13775.
BC063817 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:6502986), partial cds.
BC031471 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:3880754), partial cds.
AY304473 - Homo sapiens WD40 repeat protein 26 (WDR26) mRNA, complete cds.
JD385656 - Sequence 366680 from Patent EP1572962.
JD344308 - Sequence 325332 from Patent EP1572962.
JD171494 - Sequence 152518 from Patent EP1572962.
JD309590 - Sequence 290614 from Patent EP1572962.
JD391902 - Sequence 372926 from Patent EP1572962.
JD243461 - Sequence 224485 from Patent EP1572962.
JD273243 - Sequence 254267 from Patent EP1572962.
JD427219 - Sequence 408243 from Patent EP1572962.
JD331704 - Sequence 312728 from Patent EP1572962.
JD248863 - Sequence 229887 from Patent EP1572962.
JD565889 - Sequence 546913 from Patent EP1572962.
JD284226 - Sequence 265250 from Patent EP1572962.
JD299046 - Sequence 280070 from Patent EP1572962.
JD303590 - Sequence 284614 from Patent EP1572962.
JD052911 - Sequence 33935 from Patent EP1572962.
JD363740 - Sequence 344764 from Patent EP1572962.
JD502887 - Sequence 483911 from Patent EP1572962.
EF011612 - Homo sapiens CDW2/WDR26 mRNA, complete cds.
BC052301 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone MGC:59723 IMAGE:6420398), complete cds.
BC034498 - Homo sapiens WD repeat domain 26, mRNA (cDNA clone IMAGE:4831010), partial cds.
AK024669 - Homo sapiens cDNA: FLJ21016 fis, clone CAE05735.
AK225061 - Homo sapiens mRNA for WD repeat domain 26 variant, clone: CAE05735.
AK299230 - Homo sapiens cDNA FLJ56418 complete cds, highly similar to WD repeat protein 26.
JD538596 - Sequence 519620 from Patent EP1572962.
JD484539 - Sequence 465563 from Patent EP1572962.
JD314000 - Sequence 295024 from Patent EP1572962.
AB385130 - Synthetic construct DNA, clone: pF1KB5596, Homo sapiens WDR26 gene for WD repeat protein 26, complete cds, without stop codon, in Flexi system.
AK307909 - Homo sapiens cDNA, FLJ97857.
AB586698 - Homo sapiens mRNA, IgA nephropathy-related cDNA 4.
AF130049 - Homo sapiens clone FLB3411 PRO0852 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A0MNN3, CDW2, MIP2, NM_025160, NP_079436, PRO0852, Q4G100, Q59EC4, Q5GLZ9, Q86UY4, Q9H3C2, Q9H7D7, WDR26_HUMAN
UCSC ID: uc001hop.4
RefSeq Accession: NM_025160
Protein: Q9H7D7 (aka WDR26_HUMAN or WD26_HUMAN)
CCDS: CCDS31037.2

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene WDR26:
wdr26-id (WDR26-Related Intellectual Disability)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_025160.6
exon count: 14CDS single in 3' UTR: no RNA size: 6884
ORF size: 1986CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3985.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.