Mouse Gene Ripk3 (ENSMUST00000178399.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus receptor-interacting serine-threonine kinase 3 (Ripk3), transcript variant 2, mRNA. (from RefSeq NM_001164107)
Gencode Transcript: ENSMUST00000178399.2
Gencode Gene: ENSMUSG00000022221.14
Transcript (Including UTRs)
   Position: mm10 chr14:55,784,997-55,788,857 Size: 3,861 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm10 chr14:55,785,197-55,788,105 Size: 2,909 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:55,784,997-55,788,857)mRNA (may differ from genome)Protein (422 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9PZP3_MOUSE
DESCRIPTION: SubName: Full=Receptor-interacting serine/threonine-protein kinase 3;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -131.70396-0.333 Picture PostScript Text
3' UTR -49.50200-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR025735 - RHIM_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12721 - RIP homotypic interaction motif

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on E9PZP3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation


-  Descriptions from all associated GenBank mRNAs
  LF199979 - JP 2014500723-A/7482: Polycomb-Associated Non-Coding RNAs.
BC029210 - Mus musculus receptor-interacting serine-threonine kinase 3, mRNA (cDNA clone MGC:35896 IMAGE:3590770), complete cds.
AF178953 - Mus musculus receptor interacting protein 3 (Rip3) mRNA, complete cds.
AK012177 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610528K09 product:receptor-interacting serine-threonine kinase 3, full insert sequence.
AK154505 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630040N18 product:receptor-interacting serine-threonine kinase 3, full insert sequence.
LF241059 - JP 2014500723-A/48562: Polycomb-Associated Non-Coding RNAs.
LF203207 - JP 2014500723-A/10710: Polycomb-Associated Non-Coding RNAs.
LF241061 - JP 2014500723-A/48564: Polycomb-Associated Non-Coding RNAs.
MA435556 - JP 2018138019-A/7482: Polycomb-Associated Non-Coding RNAs.
MA476636 - JP 2018138019-A/48562: Polycomb-Associated Non-Coding RNAs.
MA438784 - JP 2018138019-A/10710: Polycomb-Associated Non-Coding RNAs.
MA476638 - JP 2018138019-A/48564: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04623 - Cytosolic DNA-sensing pathway

-  Other Names for This Gene
  Alternate Gene Symbols: E9PZP3, E9PZP3_MOUSE, NM_001164107, uc007uaw.1, uc007uaw.2, uc007uaw.3
UCSC ID: uc007uaw.3
RefSeq Accession: NM_001164107
Protein: E9PZP3 CCDS: CCDS49499.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.