Human Gene PDE4B (ENST00000329654.8) from GENCODE V38
  Description: Homo sapiens phosphodiesterase 4B (PDE4B), transcript variant e, mRNA. (from RefSeq NM_001297440)
RefSeq Summary (NM_001037341): This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gencode Transcript: ENST00000329654.8
Gencode Gene: ENSG00000184588.18
Transcript (Including UTRs)
   Position: hg38 chr1:65,792,514-66,374,278 Size: 581,765 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg38 chr1:65,913,315-66,372,678 Size: 459,364 Coding Exon Count: 16 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:65,792,514-66,374,278)mRNA (may differ from genome)Protein (736 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: PDE4B
Diseases sorted by gene-association score: ocular hypotension (7), acrodysostosis (6), schizophrenia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.38 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 207.73 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.90187-0.320 Picture PostScript Text
3' UTR -440.501600-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  CR749667 - Homo sapiens mRNA; cDNA DKFZp686F2182 (from clone DKFZp686F2182).
BC071607 - Homo sapiens cDNA clone IMAGE:5262278, containing frame-shift errors.
BC036108 - Homo sapiens cDNA clone IMAGE:5284784, containing frame-shift errors.
AK289969 - Homo sapiens cDNA FLJ75596 complete cds, highly similar to Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), mRNA.
L20966 - Human phosphodiesterase mRNA, complete cds.
BC101480 - Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), mRNA (cDNA clone MGC:126529 IMAGE:8068986), complete cds.
BC105040 - Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), mRNA (cDNA clone MGC:132700 IMAGE:8144043), complete cds.
AB590564 - Synthetic construct DNA, clone: pFN21AE2072, Homo sapiens PDE4B gene for phosphodiesterase 4B, cAMP-specific, without stop codon, in Flexi system.
KJ534916 - Homo sapiens clone PDE4B_iso-A_adult-A03 phosphodiesterase 4B cAMP-specific isoform A (PDE4B) mRNA, partial cds, alternatively spliced.
KJ534917 - Homo sapiens clone PDE4B_iso-B_fetal-F05 phosphodiesterase 4B cAMP-specific isoform B (PDE4B) mRNA, partial cds, alternatively spliced.
KJ535082 - Homo sapiens clone PDE4B_iso-C_adult-A16 phosphodiesterase 4B cAMP-specific isoform C (PDE4B) mRNA, complete cds, alternatively spliced.
KJ897309 - Synthetic construct Homo sapiens clone ccsbBroadEn_06703 PDE4B gene, encodes complete protein.
AB209081 - Homo sapiens mRNA for phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) variant protein.
AK290006 - Homo sapiens cDNA FLJ75521 complete cds, highly similar to Homo sapiens cyclic AMP specific phosphodiesterase mRNA.
U85048 - Homo sapiens cyclic AMP specific phosphodiesterase mRNA, partial cds.
L20971 - Human phosphodiesterase mRNA, complete cds.
M97515 - Human rolipram-sebsitive, cAMP-specific phosphodiesterase (PDE2) mRNA, complete cds.
L12686 - Homo sapiens 3',5'-cyclic AMP phosphodiesterase mRNA, 3'end.
AK294441 - Homo sapiens cDNA FLJ56619 complete cds, highly similar to cAMP-specific 3',5'-cyclic phosphodiesterase4B (EC
AK290206 - Homo sapiens cDNA FLJ75295 complete cds.
EF595686 - Homo sapiens cAMP-specific phosphodiesterase-4 B isoform (PDE4B5) mRNA, complete cds.
AK000989 - Homo sapiens cDNA FLJ10127 fis, clone HEMBA1002973, moderately similar to CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC
AK127365 - Homo sapiens cDNA FLJ45439 fis, clone BRSSN2004710.
JD431351 - Sequence 412375 from Patent EP1572962.
JD216291 - Sequence 197315 from Patent EP1572962.
JD506559 - Sequence 487583 from Patent EP1572962.
JD085814 - Sequence 66838 from Patent EP1572962.
JD063716 - Sequence 44740 from Patent EP1572962.
JD262823 - Sequence 243847 from Patent EP1572962.
BC046161 - Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila), mRNA (cDNA clone IMAGE:4393859).
JD301961 - Sequence 282985 from Patent EP1572962.
JD049229 - Sequence 30253 from Patent EP1572962.
JD418965 - Sequence 399989 from Patent EP1572962.
JD200385 - Sequence 181409 from Patent EP1572962.
JD422470 - Sequence 403494 from Patent EP1572962.
JD186254 - Sequence 167278 from Patent EP1572962.
JD361082 - Sequence 342106 from Patent EP1572962.
JD077933 - Sequence 58957 from Patent EP1572962.
JD242195 - Sequence 223219 from Patent EP1572962.
JD416186 - Sequence 397210 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000329654.1, ENST00000329654.2, ENST00000329654.3, ENST00000329654.4, ENST00000329654.5, ENST00000329654.6, ENST00000329654.7, NM_001297440, uc001dcn.1, uc001dcn.2, uc001dcn.3, uc001dcn.4, X5DNX5
UCSC ID: ENST00000329654.8
RefSeq Accession: NM_001037341

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.