Human Gene ZYG11A (ENST00000371532.5) from GENCODE V38
  Description: Homo sapiens zyg-11 family member A, cell cycle regulator (ZYG11A), transcript variant 2, mRNA. (from RefSeq NM_001307931)
Gencode Transcript: ENST00000371532.5
Gencode Gene: ENSG00000203995.10
Transcript (Including UTRs)
   Position: hg38 chr1:52,842,511-52,894,998 Size: 52,488 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr1:52,860,749-52,892,957 Size: 32,209 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:52,842,511-52,894,998)mRNA (may differ from genome)Protein (417 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein zyg-11 homolog A;
FUNCTION: Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC (By similarity).
SIMILARITY: Belongs to the zyg-11 family.
SIMILARITY: Contains 3 LRR (leucine-rich) repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.95 RPKM in Testis
Total median expression: 8.84 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -307.90647-0.476 Picture PostScript Text
3' UTR -816.802041-0.400 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold

ModBase Predicted Comparative 3D Structure on Q6WRX3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0016567 protein ubiquitination
GO:0051438 regulation of ubiquitin-protein transferase activity

Cellular Component:
GO:0031462 Cul2-RING ubiquitin ligase complex

-  Descriptions from all associated GenBank mRNAs
  AY271826 - Homo sapiens ZYG-11A early embryogenesis protein mRNA, complete cds.
BC119789 - Homo sapiens zyg-11 homolog A (C. elegans), mRNA (cDNA clone IMAGE:40108271), with apparent retained intron.
BC119815 - Homo sapiens zyg-11 homolog A (C. elegans), mRNA (cDNA clone IMAGE:40108269), with apparent retained intron.
DQ575538 - Homo sapiens piRNA piR-43650, complete sequence.
JD364588 - Sequence 345612 from Patent EP1572962.
JD384820 - Sequence 365844 from Patent EP1572962.
JD374599 - Sequence 355623 from Patent EP1572962.
JD220949 - Sequence 201973 from Patent EP1572962.
JD409333 - Sequence 390357 from Patent EP1572962.
JD489460 - Sequence 470484 from Patent EP1572962.
JD489461 - Sequence 470485 from Patent EP1572962.
JD257273 - Sequence 238297 from Patent EP1572962.
JD426799 - Sequence 407823 from Patent EP1572962.
JD312165 - Sequence 293189 from Patent EP1572962.
JD346648 - Sequence 327672 from Patent EP1572962.
JD356717 - Sequence 337741 from Patent EP1572962.
DQ589559 - Homo sapiens piRNA piR-56671, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NCK5, ENST00000371532.1, ENST00000371532.2, ENST00000371532.3, ENST00000371532.4, NM_001307931, Q6WRX3, uc001cul.1, uc001cul.2, uc001cul.3, ZY11A_HUMAN, ZYG11
UCSC ID: ENST00000371532.5
RefSeq Accession: NM_001307931
Protein: Q6WRX3 (aka ZY11A_HUMAN)
CCDS: CCDS76166.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.